Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (9): 1955-1960.DOI: 10.6023/cjoc201504007 Previous Articles     Next Articles



林亚伟a, 王立平b, 王乂a, 王伟a, 郝杰杰a, 朱伟明a   

  1. a 中国海洋大学医药学院 海洋药物教育部重点实验室 青岛 266003;
    b 贵州省及中国科学院天然产物化学重点实验室 贵阳 550002
  • 收稿日期:2015-04-07 修回日期:2015-05-06 发布日期:2015-05-14
  • 通讯作者: 王乂, 朱伟明;
  • 基金资助:

    国家自然科学基金(Nos. 81373298 & 21172204)、高科技发展计划(Nos. 2013AA092901 & 2012AA092104)以及国家自然科学基金-山东联合资助海洋研究中心(No. U1406402)资助项目.

Bioactive Natural Products of Aspergillus sp. OUCMDZ-1914, an Aciduric Fungus from the Mangrove Soils

Lin Yaweia, Wang Lipingb, Wang Yia, Wang Weia, Hao Jiejiea, Zhu Weiminga   

  1. a Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003;
    b Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002
  • Received:2015-04-07 Revised:2015-05-06 Published:2015-05-14
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 81373298 & 21172204), the National High-Tech R&D Program of China (Nos. 2013AA092901 & 2012AA092104), and the NSFC-Shandong Joint Fund for Marine Science Research Centers (No. U1406402).

In order to investigate bioactive metabolites from aciduric fungi, Aspergillus sp. OUCMDZ-1914 was isolated from the mangrove soil in Wenchang Hainan, China. The strain was fermented under low pH and the products were extracted and the extract was purified by column chromatography over silica gel, Sephadex LH-20 and semi-preparative HPLC. The structures were identified by means of NMR, MS, UV, IR and X-ray single crystal diffraction. As a results, a new compound, methyl (2Z,3E,5E,7E,9E)-4,10-dimethyl-11-(2,5-dioxopyrrolidin-3-yl)-2-(2-hydroxyethylidene)-11-oxoundeca-3,5,7,9-tetraenoate (1), along with eight known ones, RKB-3384A (2), JBIR-74 (3), JBIR-75 (4), secalonic acid D (5), oxaline (6), meleagrin (7), okaramine H (8) and citreorosein (9), was obtained. Compound 2 showed H1N1 influenza virus inhibition with an IC50 value of 116.2 μmol/L. Compound 5 showed cytotoxicities against A549, MCF-7 and K562 cell lines with the IC50 values of 0.23, 4.45 and 3.68 μmol/L respectively. Compound 6 showed α-glucosidase inhibition with an IC50 value of 0.84 mmol/L.

Key words: mangrove fungi, natural products, bioactivities