Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (10): 2102-2107.DOI: 10.6023/cjoc201505044 Previous Articles     Next Articles



宋鑫明, 周学明, 李小宝, 郑彩娟, 黄国雷, 余章昕, 宋小平, 陈光英   

  1. 海南师范大学化学与化工学院 海南师范大学热带药用植物化学教育部重点实验室 海口 571158
  • 收稿日期:2015-05-27 修回日期:2015-06-15 发布日期:2015-06-24
  • 通讯作者: 李小宝, 郑彩娟
  • 基金资助:

    国家自然科学基金(Nos. 21462015, 21362009, 31360069)、海南省自然科学基金(Nos. 20152037, 20152034)及海南师范大学科研启动基金(No. QN1434)资助项目.

Secondary Metabolites of a Bruguiera sexangula var. Rhynchopetala-Derived Fungus Phomopsis longicolla HL-2232

Song Xinming, Zhou Xueming, Li Xiaobao, Zheng Caijuan, Huang Guolei, Yu Zhangxin, Song Xiaoping, Chen Guangying   

  1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
  • Received:2015-05-27 Revised:2015-06-15 Published:2015-06-24
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21462015,21362009, 31360069), the Natural Science Foundation of Hainan Province (Nos. 20152037, 20152034), and the Youth Foundation of Hainan Normal University (No. QN1434).

Under the guidance of bioassay, five alkaloids, one chromone and four steroids were isolated from the Phomopsis longicolla HL-2232, a fungus isolated from a mangrove Bruguiera sexangula var. Rhynchopetala. Their structures were identified as 6-aminopurine-9-carboxylic acid methyl ester (1), adenine riboside (2), uridine (3), N,N'-diphenyl urea (4), (2S,2'R,3R,4E,8E,3'E)-2-(2'-hydroxy-3'-octadecenoylamino)-9-methyl-4,8-octadecadiene-l,3-diol (5), 2-(2'S-hydroxypropyl)-5-methyl-7-hydroxychromone (6), fortisterol (7), (22E)-5α,8α-epidioxyergosta-6,22-dien-3β-ol (8), cerevisterol (9) and β-sitosteryl linoleate (10). Among them, compound 1 was a new compound. Compound 5 was a new natural product, and its 13C NMR spectroscopic data has not reported until now. Compounds 13 showed inhibitory activities against B16F10, A549, HL-60 and MCF-7. Compounds 1 and 3 exhibited the higher inhibitory activities against MCF-7 and A549 than positive control cisplatin with IC50 values of 14.9 and 8.6 μmol·L-1, respectively.

Key words: Bruguiera sexangula var. Rhynchopetala, Phomopsis longicolla, secondary metabolity, alkaloid, cototoxic activity