Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (5): 1295-1299.DOI: 10.6023/cjoc201702043 Previous Articles     Next Articles



吴访, 张文景, 安冬丽, 李岩云, 高景星   

  1. 厦门大学化学化工学院 醇醚酯化工清洁生产国家工程实验室 厦门 361005
  • 收稿日期:2017-02-27 修回日期:2017-04-01 发布日期:2017-04-13
  • 通讯作者: 李岩云
  • 基金资助:


Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Chiral Multidentate Aminophosphine Ligands/Iron Cluster

Wu Fang, Zhang Wenjing, An Dongli, Li Yanyun, Gao Jingxing   

  1. National Engineering Laboratory for Green Chemical Productions of Alcohols, Ethers and Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005
  • Received:2017-02-27 Revised:2017-04-01 Published:2017-04-13
  • Contact: 10.6023/cjoc201702043
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21173176, 21673190) and the Fundamental Research Funds for the Central Universities (No. 20720150040).

As one of the most abundant metals on earth, iron is cheap and low toxicity. Herein we reported the asymmetric transfer hydrogenation of (ATH) ketones catalyzed by the system generated in situ from chiral multidentate aminophosphine ligand (R,R,R,R)-PN4H6 and Fe3(CO)12. The effects of temperature and additive on the ATH of propiophenone were examined. After optimizing the reaction conditions, we applied the catalytic system to the ATH of various aromatic ketones, obtaining the corresponding optical active alcohols with high enantioselectivities (up to 96% ee).

Key words: chiral aminophosphine ligand, iron cluster, cheap metal, ketones, asymmetric transfer hydrogenation