Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (8): 1939-1951.DOI: 10.6023/cjoc201703040 Previous Articles     Next Articles



陈燚, 胡奥晗, 杨凌毅, 李早英, 严琨   

  1. 武汉大学化学与分子科学学院 武汉 430072
  • 收稿日期:2017-03-24 修回日期:2017-04-16 发布日期:2017-05-04
  • 通讯作者: 严琨
  • 基金资助:


Recent Progress in Fluorescent Probe for the Detection of Reactive Carbonyl Species

Chen Yi, Hu Aohan, Yang Lingyi, Li Zaoying, Yan Kun   

  1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072
  • Received:2017-03-24 Revised:2017-04-16 Published:2017-05-04
  • Contact: 10.6023/cjoc201703040
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21401144) and the Natural Science Foundation of Hubei Province (No. 2013CFB236).

Reactive carbonyl species (RCS) have long been known as carcinogens and human poison. Elevated levels of RCS have also been associated with pathologies. In order to elucidate these roles of RCS, the design and development technology for selective and sensitive detection to RCS in vivo are crucial. In rencent years, fluorescent probes for detecting reactive carbonyl species, reactive oxygen, reactive nitrogen, hypochlorous acid and thiols have been developed due to various advantages such as simplicity of operation, high sensitivity and selectivity, response quickly and real-time tracking in living cells. Few reviews have been made for detecting reactive carbonyl species. Therefore, in this review, a general overview of the reaction-based fluoresccent in the selected recent research is provided involving design, recognition mechanism and application of fluorescent probes for detecting reactive carbonyl species of formaldehyde, methylglyoxal, malondialdehyde, acrolein and so on. Finally, the prospect to design and applications of probes for reactive carbonyl species is given.

Key words: reactive carbonyl species, fluorescent probe, molecular design, formaldehyde, methylglyoxal