Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (11): 2895-2904.DOI: 10.6023/cjoc201705031 Previous Articles     Next Articles



何波a, 王大伟b, 杨文超a, 陈琼a, 杨光富a,b   

  1. a 华中师范大学化学学院 农药与化学生物学教育部重点实验室 武汉 430079;
    b 南开大学化学学院 元素有机化学国家重点实验室 天津 300071
  • 收稿日期:2017-05-21 修回日期:2017-06-22 发布日期:2017-07-04
  • 通讯作者: 杨光富
  • 基金资助:


Advances in Research on 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Structure and Pyrazole-Containing Herbicides

He Boa, Wang Daweib, Yang Wenchaoa, Chen Qionga, Yang Guangfua,b   

  1. a Key Laboratory of Pesticide and Chemical Biology, College of Chemistry, Central China Normal University, Wuhan 430079;
    b State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071
  • Received:2017-05-21 Revised:2017-06-22 Published:2017-07-04
  • Contact: 10.6023/cjoc201705031
  • Supported by:

    Project supported by the National Key Technology Research and Development Program of the Ministry of Science and Technology (No. 2014BAD20B01), the National Natural Science Foundation of China (No. 21372093, 21672079) and the Chinese Universities Basic Scientific Research (No. CCNU15A02011).

4-Hydroxyphenylpyruvate dioxygenase (HPPD), a target for green herbicide discovery, has recently attracted a large number of famous scientists attention owing to controlling efficacy of resistant weeds. The structures of HPPD, inhibitors binding sites, mode of action and their metabolites are summarized. The current commercial and developing pyrazole-containing herbicides of HPPD are analyzed. Based on combining theory and practical application, a direction to find or design a new inhibitor is also oriented.

Key words: 4-hydroxyphenylpyruvate dioxygenase, mode of action, binding site, herbicide