Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (4): 832-839.DOI: 10.6023/cjoc201710012 Previous Articles     Next Articles

Articles

MIL-101负载Pd纳米颗粒高效非均相催化苯并呋喃选择性C2位芳基化

徐缓, 张茂元, 黄香, 史大斌   

  1. 遵义医学院药学院 遵义 563000
  • 收稿日期:2017-10-10 修回日期:2017-12-05 出版日期:2018-04-24 发布日期:2017-12-15
  • 通讯作者: 史大斌 E-mail:sdb007.student@sina.com
  • 基金资助:

    国家自然科学基金(No.21362047)、贵州省社会发展科技攻关(No.黔科合SY[2013]3061)、贵州省科学技术基金(No.黔科合J字[2014]2175)资助项目.

Palladium Nanoparticles Supported on MIL-101 as an Efficient Heterogeneous Catalyst for Selective C2 Arylation of Benzofuran

Xu Huan, Zhang Maoyuan, Huang Xiang, Shi Dabin   

  1. School of Pharmaceutical Sciences, Zunyi Medical College, Zunyi 563000
  • Received:2017-10-10 Revised:2017-12-05 Online:2018-04-24 Published:2017-12-15
  • Contact: 10.6023/cjoc201710012 E-mail:sdb007.student@sina.com
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21362047), the Social Development Project of Guizhou Province (No. QKHSYZ-2013-3061) and the Science and Technology Foundation of Guizhou Province (No. QKHJZ-2014-2175).

MIL-101 was synthesized by hydrothermal method, and Pd/MIL-101 catalyst was prepared by supporting palladium nanoparticles on metal-organic frameworks MIL-101. The microstructure and features of the catalyst were characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM), inductive coupled plasma (ICP), high resolution transmission electron microscopy (HRTEM) and N2 adsorption, respectively. The experimental results reveal that the Pd nanoparticles on Pd/MIL-101 range from 1.5 nm to 2.5 nm, and the content of Pd nanoparticles is 1.5%. The catalytic experiments show that Pd/MIL-101 has a high catalytic activity for the C2 arylation of benzofuran. For less active aryl bromides, the reaction gave moderate yields. Moreover, the catalyst could be recycled many times. After 5 runs of catalysis, the catalyst can still maintain high reactivity. This strategy provides a simple, effective method for the synthesis of benzofuran derivatives.

Key words: metal-organic frameworks (MOFs), Pd nanoparticles, heterogeneous catalysis, C-H activation, benzofuran