Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (10): 2784-2790.DOI: 10.6023/cjoc201801040 Previous Articles     Next Articles



崔朋雷a,b, 刘娜a, 陈华a, 李小六a   

  1. a 河北大学化学与环境科学学院 河北省化学生物学重点实验室 保定 071002;
    b 河北农业大学理学院 保定 071001
  • 收稿日期:2018-01-27 修回日期:2018-03-19 发布日期:2018-06-01
  • 通讯作者: 陈华,
  • 基金资助:


Synthesis and Antibacterial Activity Evaluation of the Thiouracil Derivatives Containing Benzothiazole

Cui Pengleia,b, Liu Naa, Chen Huaa, Li Xiaoliua   

  1. a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002;
    b College of Science, Agricultural University of Hebei, Baoding 071001
  • Received:2018-01-27 Revised:2018-03-19 Published:2018-06-01
  • Contact: 10.6023/cjoc201801040
  • Supported by:

    Project supported by the Science and Technology Fund of Agricultural University of Hebei (No. LG20150503)

A series of unreported thiouracil derivatives 7 containing a benzothiazole moiety were synthesized by the reaction of 4-oxo-6-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile (6) with N-(benzo[d]thiazol-2-yl)-4-(chloromethyl)-benzamide (5), which was prepared from the amidation of 2-aminobenzothiazole and 4-(chloromethyl)benzoyl chloride. The newly synthesized compounds 7 were characterized by IR, MS, NMR, and element analysis. All the compounds were evaluated for their antibacterial activities against Bacillus amyloliquefaciens, Staphylococcus aureus and Bacillus subtilis. The results of the 24-hour antibacterial test showed that some compounds had good inhibitory activities against the three tested strains.

Key words: thiouracil, benzothiazole, antibacterial activity