Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (7): 1891-1912.DOI: 10.6023/cjoc201812016 Previous Articles     Next Articles

Reviews

氟硼类荧光染料及其衍生物在肿瘤诊疗一体化中的应用

冯彤, 薛中博, 尹娟娟, 蒋旭, 冯亚青, 孟舒献   

  1. 天津大学化工学院 天津 300350
  • 收稿日期:2018-12-10 修回日期:2019-01-06 出版日期:2019-07-25 发布日期:2019-02-19
  • 通讯作者: 孟舒献 E-mail:msxmail@tju.edu.cn
  • 基金资助:

    国家自然科学基金(No.21676187)、中国国际科技计划(Nos.2012DFG41980,2016YFE0114900)资助项目.

Application of Fluoroboron Fluoresceins (BODIPYS) and Their Derivatives in the Synergistic Diagnosis and Treatment of Tumor

Feng Tong, Xue Zhongbo, Yin Juanjuan, Jiang Xu, Feng Yaqing, Meng Shuxian   

  1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350
  • Received:2018-12-10 Revised:2019-01-06 Online:2019-07-25 Published:2019-02-19
  • Contact: 10.6023/cjoc201812016 E-mail:msxmail@tju.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21676187), and the China International Science and Technology Project (Nos. 2012DFG41980, 2016YFE0114900).

Tumor is one of the diseases with the highest mortality rate in the world. In view of the high risk and high mortality of tumor, researchers around the world are committed to develop more accurate and rapid diagnostic strategies and more effective treatments to fight tumor. Gradually, integrated optical diagnosis and treatment technologies for tumors have emerged. Fluoroboron fluorescein (BODIPY) has been widely used in tumor phototherapy because of its excellent optical properties. In this paper, BODIPY and its derivatives are introduced in detail as photosensitizers, photothermal transformants, and contrast agents in the diagnosis and treatment of tumors (photodynamic therapy, photothermal therapy, photoacoustic imaging) and integration of diagnosis and treatment. The effects of different BODIPY structures and their derivatives in tumor diagnosis and treatment were evaluated systematically. This is of great significance for the rational design of near-infrared BODIPY materials with high singlet oxygen quantum yield, high photothermal conversion, and good light stability and solubility.

Key words: tumor, BODIPY, photodynamic therapy, photothermal therapy, photoacoustic imaging, synergistic theranostics