Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (7): 2084-2088.DOI: 10.6023/cjoc201810004 Previous Articles     Next Articles

Notes

无溶剂的β-卟啉甲醛与酮的Aldol反应

周详, 周菲, 贾晓良, 于佳伟, 申琦, 张运晓, 石伟民   

  1. 郑州大学化学与分子工程学院 郑州 450052
  • 收稿日期:2018-10-05 修回日期:2019-01-18 出版日期:2019-07-25 发布日期:2019-03-08
  • 通讯作者: 张运晓, 石伟民 E-mail:shiweimin@zzu.edu.cn;zhangyx@zzu.edu.cn
  • 基金资助:

    河南省科技攻关(No.192102310141)资助项目.

Solvent-Free Aldol Reaction of β-Porphyrin Formaldehyde with Ketone

Zhou Xiang, Zhou Fei, Jia Xiaoliang, Yu Jiawei, Shen Qi, Zhang Yunxiao, Shi Weimin   

  1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052
  • Received:2018-10-05 Revised:2019-01-18 Online:2019-07-25 Published:2019-03-08
  • Contact: 10.6023/cjoc201810004 E-mail:shiweimin@zzu.edu.cn;zhangyx@zzu.edu.cn
  • Supported by:

    Project supported by the Science and Technology Planning Project of Henan Province of China (No. 192102310141).

A convenient approach for the synthesis of β-substituted α,β-unsaturated carbonyl porphyrin compounds via base-catalyzed aldol reaction was developed. By this method, a series of β-substituted α,β-unsaturated carbonyl porphyrin compounds were constructed using β-porphyrin formaldehyde and ketones with moderate to excellent yields under mild reaction conditions, especially solvent-free, and good functional group tolerance. Furthermore, this process was successfully applied to the reactions of different metal porphyrin which have been reported to have poor reaction effects with good yields.

Key words: metal porphyrin, α,β-unsaturated carbonyl, aldol reaction, solvent-free