Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (7): 2650-2665.DOI: 10.6023/cjoc202011018 Previous Articles     Next Articles


赵芳a, 叶文静a,b,*(), 王凯a,*()   

  1. a 湖北大学有机功能分子合成与应用教育部重点实验室 武汉 430062
    b 湖北大学药物高通量筛选技术国家地方联合工程研究中心 武汉 430062
  • 收稿日期:2020-11-12 修回日期:2021-01-31 发布日期:2021-03-12
  • 通讯作者: 叶文静, 王凯
  • 基金资助:

Advancement of Chiral Monodentate Phosphite Ligands in Asymmetric Hydrogenation

Fang Zhaoa, Wenjing Yea,b(), Kai Wanga()   

  1. a Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecule, Hubei University, Wuhan 430062
    b National & Local Joint Engineering Research Center of High-Throughput Drug Screening Technology, Hubei University, Wuhan 430062
  • Received:2020-11-12 Revised:2021-01-31 Published:2021-03-12
  • Contact: Wenjing Ye, Kai Wang
  • Supported by:
    Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University(KLSAOFM1910)

Since the 21st century, the study of chiral monophosphorous ligands, especially chiral mono-phosphites ligands and mono-phosphoramidites ligands has attracted widespread attention. This kind of ligands was extensively used in various asymmetric catalytic reactions, for most of them were easily synthesized and showed good stability, high activity and high enantioselectivity. The diverse common monodentate phosphonites, phosphites, and phosphoramidites ligands and their applications in asymmetric hydrogenations over the past two decades are reviewed.

Key words: phosphites, phosphoramidites, phosphonites, monodentate ligands, asymmetric hydrogenation