Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (8): 3106-3115.DOI: 10.6023/cjoc202102035 Previous Articles     Next Articles



葛雅欣a, 闫芹芹a, 田云飞b,*(), 王海军a, 张春芳a,*(), 李泽江a,*()   

  1. a 河北大学化学与环境科学学院 药物化学与分子诊断教育部重点实验室 河北省化学生物学重点实验室 河北保定 071002
    b 洛阳师范学院化学化工学院 河南省功能导向多孔材料重点实验室 河南洛阳 471934
  • 收稿日期:2021-02-20 修回日期:2021-04-17 发布日期:2021-06-02
  • 通讯作者: 田云飞, 张春芳, 李泽江
  • 基金资助:
    国家自然科学基金(21702044); 国家自然科学基金(11704024); 国家自然科学基金(21973024); 河北省自然科学基金(B2020201014); 河北省自然科学基金(B2020201006); 河北省高等学校科学技术研究(QN2019063); 河南省高等学校重点科研(21A150038); 河南省自然科学基金(162300410200)

Metal-Free-Involved Cascade Cyclization of Unsaturated Amides with Polychloromethanes

Yaxin Gea, Qinqin Yana, Yunfei Tianb(), Haijun Wanga, Chunfang Zhanga(), Zejiang Lia()   

  1. a Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry & Environmental Science, Hebei University, Baoding, Hebei 071002
    b Henan Key Laboratory of Function-Oriented Porous Materia, College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang, Henan 471934
  • Received:2021-02-20 Revised:2021-04-17 Published:2021-06-02
  • Contact: Yunfei Tian, Chunfang Zhang, Zejiang Li
  • Supported by:
    National Natural Science Foundation of China(21702044); National Natural Science Foundation of China(11704024); National Natural Science Foundation of China(21973024); Natural Science Foundation of Hebei Province(B2020201014); Natural Science Foundation of Hebei Province(B2020201006); Science and Technology Project of Hebei Education Department(QN2019063); Key Scientific Research Project of Higher Education of Henan Province(21A150038); Natural Science Foundation of Henan Province(162300410200)

Free radical initiated cascade cyclization of unsaturated amides with polychloromethanes provides a protocol for the selective synthesis of polychlorinated isoquinolinones, or dihydroisoquinolinones. A series of mechanistic studies and optical experiments were operated in this system.

Key words: unsaturated amide, polychloromethane, radical reaction, isoquinolinone, dihydroisoquinolinone