Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (3): 901-904.DOI: 10.6023/cjoc202109024 Previous Articles     Next Articles


海绵Spongia sp.中一个新的D环为吡啶环的降海绵烷型二萜

梁咏倩a,b, 廖小建a, 凌珑a, 杨雅婷a, 赵冰心a,*(), 徐石海a,*()   

  1. a 暨南大学化学与材料学院 广州 510632
    b 广东药科大学药学院 广州 510006
  • 收稿日期:2021-09-22 修回日期:2021-10-19 发布日期:2021-11-09
  • 通讯作者: 赵冰心, 徐石海
  • 作者简介:
    † 共同第一作者
  • 基金资助:
    国家重点研发计划(2019YFD0901905); 国家重点研发计划(2018YFC0310900); 国家自然科学基金(41876145); 国家自然科学基金(81874292); 国家自然科学基金(21672084); 广州市科技计划(202102010066); 广州市科技计划(201704030042)

A New Dinorspongian Diterpene with Pyridyl D-Ring from the Marine Sponge Spongia sp.

Yongqian Lianga,b, Xiaojian Liaoa, Long Linga, Yating Yanga, Bingxin Zhaoa(), Shihai Xua()   

  1. a College of Chemistry and Materials Science, Jinan University, Guangzhou 510632
    b College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006
  • Received:2021-09-22 Revised:2021-10-19 Published:2021-11-09
  • Contact: Bingxin Zhao, Shihai Xu
  • About author:
    † These authors contributed equally to this work.
  • Supported by:
    National Key Research and Development Plan of China(2019YFD0901905); National Key Research and Development Plan of China(2018YFC0310900); National Natural Science Foundation of China(41876145); National Natural Science Foundation of China(81874292); National Natural Science Foundation of China(21672084); Science and Technology Planning Project of Guangzhou(202102010066); Science and Technology Planning Project of Guangzhou(201704030042)

Chemical investigation of the marine sponge Spongia sp. led to a new dinorspongian diterpene dinorspongiapyridine (1) together with four known compounds 2~5. Compound 1 was the first instance of 3,4-seco-3,19-dinorspongian diterpene bearing a rare pyridyl D-ring system. The structure with absolute configuration of 1 was elucidated by the methods of NMR and X-ray diffraction. In addition, the cytotoxic activities against several cancer cell lines of 1 were evaluated. The plausible biogenetic pathway of 1 was also proposed.

Key words: sponge, Spongia, dinorspongian diterpene, pyridyl ring