Acta Chimica Sinica ›› 2013, Vol. 71 ›› Issue (03): 295-298.DOI: 10.6023/A13010018 Previous Articles     Next Articles

Article

中断的Fisher吲哚合成法及其在生物碱合成中的应用

李森a,b, 韩静a, 李昂b   

  1. a 沈阳药科大学制药工程学院 沈阳 110016;
    b 中国科学院上海有机化学研究所生命有机化学国家重点实验室 上海 200032
  • 收稿日期:2013-01-05 出版日期:2013-03-14 发布日期:2013-01-25
  • 通讯作者: 韩静,李昂 E-mail:hj-8080@163.com,ali@sioc.ac.cn
  • 基金资助:

    项目受科技部973计划(No.2013CB836900)、国家自然科学基金(Nos.21172235,21222202,21290180)和上海市浦江人才计划(No.12PJ1410800)和中国科学院资助.

Interrupted Fisher Indole Synthesis and Its Applications to Alkaloid Synthesis

Li Senaa,b, Han Jinga, Li Angb   

  1. a School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016;
    b State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2013-01-05 Online:2013-03-14 Published:2013-01-25
  • Supported by:

    Project supported by the National Basic Research Program (973 Program) of China (No. 2013CB836900), the Natural Science Foundation of China (Nos.21172235, 21222202, and 21290180), Shanghai Pujiang Plan (No. 12PJ1410800) and the Chinese Academy of Sciences.

Fisher indole synthesis is an important method in organic synthesis. Recently, Garg and Liang developed interrupted Fisher indole synthesis and applied it in the synthesis of a series of natural products and natural product-like compounds. Here we highlight their recent progress under this topic.

Key words: Fisher indole synthesis, [3,3]-sigmatropic rearrangement, Cu-catalyzed C—N bond formation, aspidophylline A, total synthesis