Acta Chimica Sinica ›› 2013, Vol. 71 ›› Issue (09): 1239-1242.DOI: 10.6023/A13040394 Previous Articles     Next Articles

Communication

双功能配体促进的钯催化不对称醚化和胺化反应

杜乐a,b, 曹鹏b, 廖建a,b   

  1. a 中国科学院成都有机化学研究所 成都 610041;
    b 中国科学院成都生物研究所 天然产物研究中心 成都610041
  • 投稿日期:2013-04-11 发布日期:2013-04-22
  • 通讯作者: 廖建,E-mail:jliao@cib.ac.cn E-mail:jliao@cib.ac.cn
  • 基金资助:

    项目受国家自然科学基金(Nos. 21272226, 21202160 and 21072186)资助.

Bifunctional Ligand Promoted Pd-Catalyzed Asymmetric Allylic Etherification/Amination

Du Lea,b, Cao Pengb, Liao Jiana,b   

  1. a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041;
    b Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041
  • Received:2013-04-11 Published:2013-04-22
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21272226, 21202160 and 21072186).

A serious of bissulfoxide-phosphine ligands are examined on the Bronsted basicity of sulfinyl moiety. The effect of secondary binding property of the ligand is demostrated in Pd-catalyzed asymmetric allylic etherification and amination (up to 99% ee). And the application scope of this methodology to hydrogen-donor nucleophiles is investigated.

Key words: chiral bissulfoxide-phosphine ligands, bifunctional, hydrogen bond, Pd-catalysis, allylic etherification and amination