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Acta Chimica Sinica ›› 1963, Vol. 29 ›› Issue (1): 44-53. Previous Articles     Next Articles

喹唑啉类杂环化合物的化学——Ⅲ. N1,N3-二氧化-4-羥基喹唑啉的分子重排反应

蒋明謙, 李鈞   

  1. 北京医学院药学系
  • 投稿日期:1962-06-04 发布日期:2013-06-03

CHEMISTRY OF THE QUINAZOLINE SERIES Ⅲ. MOLECULAR REARRANGEMENT OF 4-HYDROXYQUINAZOLINE DI-N-OXIDE

CHIANG MING-CHIEN(M. C. CHIANG), LI CHUN   

  1. Department of Pharmacy, Peking Medical College
  • Received:1962-06-04 Published:2013-06-03

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Upon refluxing with concentrated hydrochloric acid,4-hydroxyquinazoline dl-N-oxide (Ⅰ) undergoes rearrangement and cleavage to give 75-81% of 2,4,6-trihydroxyquinazo-line (Ⅱ),11-17% of 4-hydroxy-6-chloroquinazoline N3-oxide (Ⅳ),and 2-3% of 3,5-dichloroanthranilic acid (Ⅴ).