Acta Chimica Sinica ›› 1964, Vol. 30 ›› Issue (4): 369-380. Previous Articles     Next Articles

肿瘤的化学治疗 ⅩⅩ.与双(β-氯乙基)氨甲基苯丙氨酸有关化合物的研究(一)2-(或3-)双-(β-氯乙基)氨甲基-4-羟基-苯丙氨酸双盐酸盐的合成

任云峯, 高怡生   

  1. 中国科学院药物研究所
  • 收稿日期:1963-10-28 出版日期:1964-08-15 发布日期:2013-06-03

TUMOUR CHEMOTHERAPY ⅩⅩ. STUDIES ON BIS (β-CHLOROETHYL)-AMINOMETHYLPHENYLALANINE 1. SYNTHESES OF 2-(OR 3-)[BIS-(β-CHLOROETHYL) AMINO]-METHYL-4-HYDROXYPHENYLALANINE DIHYDROCHLORIDES

JEN YUN-FENG, KAO YEE-SHENG   

  1. Institute of Materia Medica, Academia Sinica
  • Received:1963-10-28 Online:1964-08-15 Published:2013-06-03

In a previous paper[1] of this series of investigations the syntheses of p-,m-,and o-(bis-(β-chloroethyl)-amino]-methyl-phenylalanine dihydrochlorides (Ⅱ, designated as AT-290, AT-582, and AT-581 respectively) by substituting one hydrogen atom of the methyl group of HN2 with the phenylalanyl group, had been described. In this investigation, 2-and 3-[bis-β-chloroethyl)-amino]-methyl-4-hydroxyphenylalanine dihydrochlorides (Ⅳ and Ⅴ, designated as AT-786 and AT-916 respectively) had been synthesized, however, by substituting one hydrogen atom of the methyl group of HN2 with the tyrosinyl group.