Acta Chimica Sinica ›› 1988, Vol. 46 ›› Issue (5): 483-488. Previous Articles     Next Articles

Original Articles

翼梗五味子的研究 V: 五脂素A1, A2, 表五脂A1和epischisandrone的结构

刘嘉森;陶勇;黄梅芬   

  1. 中国科学院上海药物研究所
  • 出版日期:1988-05-15 发布日期:1988-05-15

Studies on the constituents of schisandra henryi V: The structures of wulignan A1, A2, epiwulignan A1 and epischisandrone

LIU JIASEN;TAO YONG;HUANG MEIFEN   

  • Online:1988-05-15 Published:1988-05-15

Four new lignan compounds named wulignan A1(I), A2(II), epiwulignan A1(III), and epischisandrone(IV), and three known lignan compounds, enshicine, epienshicine, and schisandrone, were isolated from the fruits of Schisandra henryi Clarke collected in the district of Yibin, Sichuan Province. In anticancer screening all of the four new compounds exhibit activity against leukemia P-388 in vitro. The following new compounds, (+)-isootobaphenol, (+)-demethyleneisootobaphenol, dimethylwulignan A1, and dimethylepiwulignan A1 were prepared during the course of the structural elucidation.

Key words: ANTICARCINOGEN, MOLECULAR STRUCTURE, ABSOLUTE CONFIGURATION, WULIGNAN, SCHISANDRA CHINENSIS

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