Four new lignan compounds named wulignan A1(I), A2(II), epiwulignan A1(III), and epischisandrone(IV), and three known lignan compounds, enshicine, epienshicine, and schisandrone, were isolated from the fruits of Schisandra henryi Clarke collected in the district of Yibin, Sichuan Province. In anticancer screening all of the four new compounds exhibit activity against leukemia P-388 in vitro. The following new compounds, (+)-isootobaphenol, (+)-demethyleneisootobaphenol, dimethylwulignan A1, and dimethylepiwulignan A1 were prepared during the course of the structural elucidation.

Key words: ANTICARCINOGEN, MOLECULAR STRUCTURE, ABSOLUTE CONFIGURATION, WULIGNAN, SCHISANDRA CHINENSIS