Acta Chimica Sinica ›› 1999, Vol. 57 ›› Issue (6): 622-626. Previous Articles     Next Articles

Original Articles

α-羰基一硫代半缩醛与脂肪族脲反应合成2, 4-咪唑啉二酮衍生物

邱丽华;彭运开;邹建平;陆忠娥   

  1. 苏州医学院化学教研室;苏州大学化学化工学院
  • 出版日期:1999-06-15 发布日期:1999-06-15

Preparation of 2, 4-imidazolidinediones (hydantoins) from α-keto hemithioacetal and alkyl ureas

Qiu Lihua;Peng Yunkai;Zou Jianping;Lu Zhonge   

  • Online:1999-06-15 Published:1999-06-15

1-alkyl-5-phenyl-2, 4-imidazolidinediones (4a-4f) have been synthesized by the reaction of α-keto hemithioacetal (1) and alkylureas (3a-3f) in the slightly acidic medium. The structure of compounds (4a-4f) were confirmed by the MS, NMR, IR spectra, elementary analysis and X-ray diffraction study. This reaction provides a new convenient method for synthesis of 1, 5-disubstituted- 2, 4-imidazolidinediones.

Key words: HEMIACETAL, UREA, IMIDAZOLONE P, INFRARED SPECTROPHOTOMETRY, NMR SPECTROMETRY, MASS SPECTROGRAPHY, ELEMENTAL ANALYSIS

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