Influence of the Dosage of Mesoporous Bioactive Glass in Simulated Body Fluid on the in vitro Bioactivity Evaluation

Acta Chimica Sinica ›› 2006, Vol. 64 ›› Issue (9): 851-857. Previous Articles Next Articles

Original Articles

介孔生物活性玻璃材料在模拟体液中的用量对考察其体外生物活性的影响

黄晓晖，严晓霞，韩路，易静, 雷杰，赵东元，余承忠*

(复旦大学化学系创新材料与分子催化实验室上海 200433)

投稿日期:2005-09-30 修回日期:2006-01-12 发布日期:2006-05-15
通讯作者: 余承忠

Influence of the Dosage of Mesoporous Bioactive Glass in Simulated Body Fluid on the in vitro Bioactivity Evaluation

HUANG Xiao-Hui, YAN Xiao-Xia, HAN Lu, YI Jing, LEI Jie, ZHAO Dong-Yuan, YU Cheng-Zhong*

(Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials,
Fudan University, Shanghai 200433)

Received:2005-09-30 Revised:2006-01-12 Published:2006-05-15
Contact: YU Cheng-Zhong

Abstract

Mesoporous bioactive glass (MBG) with bone-forming bioactivity has been synthesized. By varying the MBG dosage in simulated body fluid (SBF) while the other evaluation conditions were fixed (MBG/SBF＝0.0001～0.002 g/mL), the in vitro bioactivity of MBG was studied in details by scanning electron microscopy, Fourier-transform infrared spectroscopy, and inductive coupled plasma atomic emission spectroscopy. The results show that the rate of hydroxyapatite (HA) formation on the surface of MBG was determined by the MBG dosage in SBF, and the fastest HA formation process was observed at MBG/SBF＝0.001 g/mL. Studying the influence of the dosage on the in vitro bioactivity of MBG was important to further understand the structure-bioactivity correlation of this family of biomaterials. Moreover, the choice of an ideal MBG/SBF ratio was practically advantageous for evaluating new MBG materials with better in vitro bioactivity.

Key words: mesoporous, bioactive glass, bioactivity, hydroxyapatite

Cite this article

HUANG Xiao-Hui, YAN Xiao-Xia, HAN Lu, YI Jing, LEI Jie, ZHAO Dong-Yuan, YU Cheng-Zhong*. Influence of the Dosage of Mesoporous Bioactive Glass in Simulated Body Fluid on the in vitro Bioactivity Evaluation[J]. Acta Chimica Sinica, 2006, 64(9): 851-857.

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介孔生物活性玻璃材料在模拟体液中的用量对考察其体外生物活性的影响

Influence of the Dosage of Mesoporous Bioactive Glass in Simulated Body Fluid on the in vitro Bioactivity Evaluation

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