Acta Chimica Sinica ›› 2008, Vol. 66 ›› Issue (19): 2178-2183. Previous Articles    

Reports

生物降解多功能缓释微球的制备与表征

梁晓飞a 王汉杰a 罗 浩a 田 惠a
支 敏b 王永兰b 常 津*,a

  

  1. (a天津大学材料学院纳米生物技术研究所 天津 300072)
    (b天津医科大学附属口腔医院 天津 300070)
  • 收稿日期:2007-11-14 修回日期:2008-04-02 出版日期:2008-10-14 发布日期:2008-10-14
  • 通讯作者: 常 津

Preparation and Characterization of Novel Biodegradable Multifunctional Microspheres

LIANG, Xiao-Fei a WANG, Han-Jie a LUO, Hao a TIAN, Hui a
ZHI, Min b WANG, Yong-Lan b CHANG, Jin *,a
  

  1. (a Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University, Tianjin 300072)
    (b Dental Hospital of Tianjin Medical University, Tianjin 300070)
  • Received:2007-11-14 Revised:2008-04-02 Online:2008-10-14 Published:2008-10-14
  • Contact: CHANG, Jin

Octadecyl quaternized carboxymethyl chitosan (OQCMC) was synthesized through carboxymethyl chitosan grafting with glycidyl octadecyl dimethylammonium chloride. By a solvent evaporation method, the drug delivery system was prepared based on poly(lactic-co-glycolic acid) (PLGA) block copolymers, hydroxyethyl cellulose and OQCMC, which was tried to load minocycline hydrochloride. The microspheres were characterized by TEM, quasielastic laser light scattering with a Malvern Zetasizer, 1H NMR and FTIR. The results showed that the complex delivery system was good to load the minocycline hydrochloride and could provide long-term release behaviour through drug release experiment in vitro. The drug loading efficiency of minocycline hydrochloride could reach 9.4% by using the polymer surfactant OQCMC. It is good to decrease the particle size [(166.4±0.8) nm], increase the Zeta potential and keep the stabilization of the microspheres.

Key words: quaternized chitosan, poly(lactic-co-glycolic acid)copolymer, double emulsion method, emulsion solvent