In an attempt to find novel bioactive compounds, a series of 1-dehydroabietoyl-3-substituted thiourea 4 and 4-decarboxy-4-{3-[(un)substituted anilino]-1H-1,2,4-triazol-5-yl}dehydroabietic acid 5 were synthesized from dehydroabietic acid. Compounds 4a～4k were obtained from the reaction of dehydroabietic acyl isothiocyanate with amines, and 5a～5f were prepared by the reaction of 4 with hydrazine hydrate. The structures of the title compounds were confirmed by IR, 1H NMR and 13C NMR. The preliminary biological tests display that some of the title compounds (4j, 4e, 4f and 5b) possess a fungicidal activity against B. subtilis at a test concentration (for 4j: 50 mg/L; for 4e, 4f, 5b: 100 mg/L); 4b, 4h, 4i and 5e possess a fungicidal activity against E. coli at a test concentration of 100 mg/L.

Key words: dehydroabietic acid, 1-dehydroabietoyl-3-substituted thiourea, 4-decarboxy-4-{3- [(un)substituted anilino]-1H-1,2,4-triazol-5-yl}dehydroabietic acid