Investigation on the Anti-Candida albicans Effect of Palmatine Hydrochloride Based on Microcalorimetry and Principal Component Analysis

Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (21): 2511-2516. Previous Articles Next Articles

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基于微量热法和主成分分析的盐酸巴马汀抗白色念珠菌作用的研究

孔维军^a,b 赵艳玲^a 王伽伯^a 肖小河^*,a 李祖伦^b 金城^a 代春美^a,b

(a解放军第三零二医院解放军中药研究所北京 100039) (b成都中医药大学药学院成都 611137)

投稿日期:2009-01-03 修回日期:2009-05-19 发布日期:2009-06-26
通讯作者: 孔维军 E-mail:kongwj302@126.com

Investigation on the Anti-Candida albicans Effect of Palmatine Hydrochloride Based on Microcalorimetry and Principal Component Analysis

Kong, Weijun ^a,b Zhao, Yanling^a Wang, Jiabo^a Xiao, Xiaohe^*,a Li, Zulun^b Jin, Cheng^a Dai, Chunmei ^a,b

(^a China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing 100039) (^b Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137)

Received:2009-01-03 Revised:2009-05-19 Published:2009-06-26

Abstract

Using an LKB-2277 bioactivity monitor, the metabolic power-time curves of Candida albicans (C. albicans) growth affected by palmatine hydrochloride were measured at 37 ℃, then nine quantitative thermokinetic parameters were obtained from these curves and investigated by principal component analysis (PCA) to evaluate the anti-C. albicans effect of palmatine hydrochloride. The results showed that the anti-C. albicans effect of this compound was mainly influenced by the growth rate constant (k2) and maximum power output of phase II, and could be easily, quickly and exactly evaluated by analyzing the change of these two quantitative parameters. This work provides a useful method and idea for further evaluating the anti-bacterial effect of other drugs and compounds.

Key words: palmatine hydrochloride, anti-C. albicans effect, microcalorimetry, principal component analysis

Cite this article

KONG Wei-Jun, DIAO Yan-Ling, WANG Ga-Ba, XIAO Xiao-He. Investigation on the Anti-Candida albicans Effect of Palmatine Hydrochloride Based on Microcalorimetry and Principal Component Analysis[J]. Acta Chimica Sinica, 2009, 67(21): 2511-2516.

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基于微量热法和主成分分析的盐酸巴马汀抗白色念珠菌作用的研究

Investigation on the Anti-Candida albicans Effect of Palmatine Hydrochloride Based on Microcalorimetry and Principal Component Analysis

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