Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (8): 843-849. Previous Articles     Next Articles

Original Articles

多重响应性介孔二氧化硅纳米微球的制备及载药研究

刘聪颖 胡建华* 杨 东 杨武利*

  

  1. (复旦大学高分子科学系 聚合物分子工程教育部重点实验室 上海 200433)

  • 收稿日期:2009-03-12 修回日期:2009-03-30 出版日期:2009-04-28 发布日期:2009-04-28
  • 通讯作者: 胡建华

Preparation of Multi-responsive Mesoporous Silica Microspheres and Its Application in Controlled Drug Release

Liu, Congying Hu, Jianhua* Yang, Dong Yang, Wuli*

  

  1. (Education Ministry Key Laboratory of Molecular Engineering of Polymer, Department of Macromolecular Science,
    Fudan University, Shanghai 200433)
  • Received:2009-03-12 Revised:2009-03-30 Online:2009-04-28 Published:2009-04-28
  • Contact: Hu Jian-Hua

Magnetic mesoporous silica nanoparticles (M-MSN) were prepared via sol-gel technology with oil stabilized Fe3O4 as the core and cetytrimethylammonium bromide (CTAB) as the template. Then P(NIPAM-co-NHMA) copolymer was modified to the magnetic mesoporous silica nanoparticles to prepare a kind of multi-responsive mesoporous silica microspheres, P(NIPAM-co-NHMA)@M-MSN(-COOH), through chain transfer reaction. Brunauer-Emmett-Teller (BET), vibrating-sample magnetometer (VSM), transmission electron microscopy (TEM) and UV/vis spectra were used to characterize the multi-responsive microspheres. DOX was used as a model drug to measure the drug loading and controlled drug releasing properties. The result indicated that the multi-responsive microspheres exhibited an excellent drug loading capacity of 48% and controlled drug releasing could be obtained by changing the temperature and pH values.

Key words: multi-responsive, mesoporous silica, drug loading, controlled drug releasing