Assignments of 13C and 1H spectra of morphine and codeine have been confirmed by heteronuclear chem. shift correlated and NOESY techniques. The configuration features of morphine were analyzed, particularly the configuration of hydrogen bonding between the morphine nitrogen and the solvent impurity CHD2OH. The NOESY experiments clearly showed the cross peaks between the proton of hydrogen bonding and the protons above the piperidine ring of morphine. These cross peaks imply that the hydrogen bonding is above the piperidine ring.

Key words: MORPHINUM, RELAXATION, CHEMICAL SHIFT, HYDROGEN BONDS, CONFIGURATION, 2D NMR SPECTROMETRY