Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (8): 857-862. Previous Articles     Next Articles

Original Articles


刘晓英 陈 伟 洪 震*


  1. (复旦大学附属华山医院神经病学研究所 上海 200040)

  • 收稿日期:2009-03-21 修回日期:2009-03-30 出版日期:2009-04-28 发布日期:2009-04-28
  • 通讯作者: 洪震

Preparation and Characterization of Cross-linked Polyion Micelles Formed by Polyaspartic Acid Derivates

Liu, Xiaoying Chen, Wei Hong, Zhen*


  1. (Institute of Neurology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai 200040)
  • Received:2009-03-21 Revised:2009-03-30 Online:2009-04-28 Published:2009-04-28
  • Contact: Hong, Zhen

Two kinds of polyaspartic acid (PAsp) derivates, i.e. PEG-g-PAsp and PEG-g-PDEA, were prepared through the ring-opening reaction of polysuccinimide by CH3O-PEG-NH2, followed by alkaline hydrolysis and aminolysis, respectively. Utilizing the electrostatic interaction between them, polyion micelles with PEG shell and PAsp complex core were formed in phosphate buffer. The results showed that the polyion micelles are spherical with an average diameter of about 70 nm, and the size distribution is narrow. However, the stability of polyion micelles was strongly affected by pH and ionic strength. Crosslinking of primary amine contained in PEG-g-PDEA by glutaric dialdehyde could effectively improve the stability of polyion micelles to pH and ionic strength.

Key words: polyion micelles, polyaspartic acid, polysuccinimide, cross-linked, core-shell structure