Studies on the asymmetric synthesis of (R)-α-alkyl-furfuryl amines

Acta Chimica Sinica ›› 1993, Vol. 51 ›› Issue (1): 73-78. Previous Articles Next Articles

Original Articles

(R)-α-烷基糠胺的不对称合成

刘桂兰;胡文浩;邓金根;宓爱巧;蒋耀忠

中国科学院成都有机化学研究所

发布日期:1993-01-15

Studies on the asymmetric synthesis of (R)-α-alkyl-furfuryl amines

LIU GUILAN;HU WENHAO;DENG JINGEN;MI AIQIAO;JIANG YAOZHONG

Published:1993-01-15

Abstract

(R)-α-alkyl-furfuryl amines are synthesized by asymmetric alkylation of (+)-camphor ketimine (3) from furfuryl amine. the diastereoselectivities ranging from 5～67% are determined by 1H NMR spectra of alkylation products (6a～6e). using 1, 3-diiodopropane and dibromoxyiene as alkylatingreagents, diimine dervatives (6f～6g) are formed. however, 1,2-dibromothane gives coupling product (6h).

Key words: FURAN P, ALKYLATION, CONFIGURATION, CAMPHOR, FURFURYL AMINE

CLC Number:

O621

Cite this article

LIU GUILAN;HU WENHAO;DENG JINGEN;MI AIQIAO;JIANG YAOZHONG. Studies on the asymmetric synthesis of (R)-α-alkyl-furfuryl amines[J]. Acta Chimica Sinica, 1993, 51(1): 73-78.

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(R)-α-烷基糠胺的不对称合成

Studies on the asymmetric synthesis of (R)-α-alkyl-furfuryl amines

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