Thiazolidine is readily converted into 2-substituted derivatives I [R = D, Me, Et, Bu, hexyl, octyl, CH2Ph, CO2H, CPh2OH, CH(OH)C6H4Me-4] in a 1-pot lithiation procedure, with CO2 as both an N protection agent and as an intermediate carbanion-stabilizing group. The procedure has 4 stages: (1) protection of the NH group by lithiation and subsequent treatment with CO2 to form the Li carbamate; (2) lithiation by Me3CLi to form the carbanion; (3) introduction of a substituent by reaction with an electrophile; (4) acidic removal of the N protecting group. The yields of the products are mostly moderate.

Key words: THIAZOLE P, CARBON DIOXIDE, CONSERVATION, ACTIVATING AGENT, NUCLEOPHILIC REACTION, CHEMICAL REAGENT, ELECTROPHILIC REACTION