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Acta Chimica Sinica ›› 2007, Vol. 65 ›› Issue (8): 693-698. Previous Articles Next Articles
Original Articles
贾宏瑛1, 杨更亮*,1,2, 辛培勇1, 陈义1
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JIA Hong-Ying1; YANG Geng-Liang*,1,2; XIN Pei-Yong1; CHEN Yi1
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Brij35 micellar liquid chromatography (MLC) was presented for prediction of the octanol-water partition coefficient (log P) of drugs by comparing the retention factors of drugs in different surfactants with log P in literature. The results showed that the retention factors of drugs in Brij35 MLC were related with log P of drugs in literature. The effect of Brij35 concentration on the retention of drugs was studied and the relationship was established between the retention factors of drugs in surfactant of different concentration and log P. This method is simple, rapid and can provide valuable reference information for hydrophobicity of drugs.
Key words: micellar liquid chromatography, surfactant Brij35, octanol-water partition coefficient log P
JIA Hong-Ying; YANG Geng-Liang*,1,2; XIN Pei-Yong; CHEN Yi. Prediction of Octanol-Water Partition Coefficients (log P) of Drugs by Micellar Liquid Chromatography Simulating Biomembrane[J]. Acta Chimica Sinica, 2007, 65(8): 693-698.
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