Study on the Interaction of Sodium Deoxycholate with Supported Bilayer Lipid Membrane by Electrochemistry Method

Acta Chimica Sinica ›› 2007, Vol. 65 ›› Issue (3): 239-245. Previous Articles Next Articles

Original Articles

脱氧胆酸钠与支撑磷脂双层膜作用的电化学研究

王建国*, 江黎丽, 惠飞, 杨薇薇, 吕慧, 孙巧花

(辽宁大学化学科学与工程学院沈阳 110036)

投稿日期:2006-06-19 修回日期:2006-09-04 发布日期:2007-02-14
通讯作者: 王建国

Study on the Interaction of Sodium Deoxycholate with Supported Bilayer Lipid Membrane by Electrochemistry Method

WANG Jian-Guo*; JIANG Li-Li; HUI Fei; YANG Wei-Wei; LÜ Hui; SUN Qiao-Hua

(Institute of Chemical Sciences and Engineering, Liaoning University, Shenyang 110036)

Received:2006-06-19 Revised:2006-09-04 Published:2007-02-14
Contact: WANG Jian-Guo

Abstract

In this paper, supported bilayer lipid membrane (s-BLM) was served as a biomembrane model. The interaction between sodium deoxycholate (NaDC) and s-BLM was investigated by means of cyclic voltammetry and ac impedance spectroscopy. The results show that NaDC can decrease the orderliness of lecithin molecule and induce pores or defects on s-BLM. The interaction between them depends on time, concentration, pH and cholesterol. The defective s-BLM after interaction can be self-repaired in 0.1 mol/L KCl solution, which indicates that the interaction is reversible.

Key words: supported bilayer lipid membrane, cyclic voltammetry, ac impedance spectroscopy, sodium deoxycholate

Cite this article

WANG Jian-Guo*; JIANG Li-Li; HUI Fei; YANG Wei-Wei; LÜ Hui; SUN Qiao-Hua. Study on the Interaction of Sodium Deoxycholate with Supported Bilayer Lipid Membrane by Electrochemistry Method[J]. Acta Chimica Sinica, 2007, 65(3): 239-245.

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脱氧胆酸钠与支撑磷脂双层膜作用的电化学研究

Study on the Interaction of Sodium Deoxycholate with Supported Bilayer Lipid Membrane by Electrochemistry Method

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