Electrochemical studies of antitumor drugs I. Fundamental electrochemical characteristics of an iron(III) Schiff base complex and its interaction with DNA

Acta Chimica Sinica ›› 1998, Vol. 56 ›› Issue (2): 178-183. Previous Articles Next Articles

Original Articles

新癌药物的电化学研究1: 一种Fe(III) Schiff碱配合物的基本电化学性质及其与DNA的相互作用

赵元弟;庞代文;王宗礼;程介克;乐芝凤;冯长建;沈昊宇;张香才

武汉大学化学系;华中师范大学化学系

发布日期:1998-02-15

Electrochemical studies of antitumor drugs I. Fundamental electrochemical characteristics of an iron(III) Schiff base complex and its interaction with DNA

ZHAO YUANDI;PANG DAIWEN;WANG ZONGLI;CHENG JIEKE;LE ZHIFENG;FENG CHANGJIAN;SHEN HAOYU;ZHANG XIANGCAI

Published:1998-02-15

Abstract

The fundamental electrochemical characteristics of a synthetic iron(III) Schiff base complex has been studied. It has been found that the complex could interact with oxygen, thus being capable of absorbing oxygen. It exhibits catalytic activity toward the electroreduction of oxygen. The complex also interacts strongly with dsDNA, in particular, the iron(II) form of the Schiff base complex is easier to bind dsDNa than the iron(III) form. The biological activity and the pharmacological acting process of the Schiff base complex might be related to its absorbing of oxygen, catalytic activity and interaction with DNA.

Key words: DEOXYRIBONUCLEIC ACID, ANTICARCINOGEN, IRON COMPLEX, SCHIFF BASE, CHEMICAL MODIFIED ELECTRODE, INTERACTIONS

CLC Number:

O646

Cite this article

ZHAO YUANDI;PANG DAIWEN;WANG ZONGLI;CHENG JIEKE;LE ZHIFENG;FENG CHANGJIAN;SHEN HAOYU;ZHANG XIANGCAI. Electrochemical studies of antitumor drugs I. Fundamental electrochemical characteristics of an iron(III) Schiff base complex and its interaction with DNA[J]. Acta Chimica Sinica, 1998, 56(2): 178-183.

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新癌药物的电化学研究1: 一种Fe(III) Schiff碱配合物的基本电化学性质及其与DNA的相互作用

Electrochemical studies of antitumor drugs I. Fundamental electrochemical characteristics of an iron(III) Schiff base complex and its interaction with DNA

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