Molecular diversity of tonghaosu analogs synthesis of 2-(Z)- benzylidene-1,6,9-trioxaspiro[4,5] dec-3-ene

Acta Chimica Sinica ›› 2001, Vol. 59 ›› Issue (10): 1756-1762. Previous Articles Next Articles

Original Articles

茼蒿素类似物的分子多样性2-(Z)-亚苄基-1,6,9-三氧杂螺环 [4,5-癸-3-烯类化合物的合成

范俊发;尹标林;张瑜峰;吴毓林;伍贻康

中国科学院上海有机化学研究所.上海(200032);中国科学院生命有机化学国家重点实验室

发布日期:2001-10-15

Molecular diversity of tonghaosu analogs synthesis of 2-(Z)- benzylidene-1,6,9-trioxaspiro[4,5] dec-3-ene

Fan Junfa;Yin Biaolin;Zhang Yufeng;Wu Yulin;Wu Yikang

Shanghai Inst Organ Chem., CAS.Shanghai(200032)

Published:2001-10-15

Abstract

By using the dehydration-spiroketalization of corresponding furanylidiols. discovered in our laboratory as the key reaction to construct the trioxaspiro[4,5]dec-3-ene nucleus, we have developed a practical synthtic reoute to thonghaosu analogs, a class of compounds characterized by a unique spiroketal enol ether motif, and thus cueated an expeditious access to the molecular diversity of this type of substances hat already show intersting activities in preliminary biological testes.

Key words: SPIRO COMPOUNDS, OXYGEN HETEROCYCLICS, BIOLOGICAL ACTIVITY, FURFURYL ALCOHOL RESINS, ANALOGUE

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Cite this article

Fan Junfa;Yin Biaolin;Zhang Yufeng;Wu Yulin;Wu Yikang. Molecular diversity of tonghaosu analogs synthesis of 2-(Z)- benzylidene-1,6,9-trioxaspiro[4,5] dec-3-ene[J]. Acta Chimica Sinica, 2001, 59(10): 1756-1762.

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茼蒿素类似物的分子多样性2-(Z)-亚苄基-1,6,9-三氧杂螺环 [4,5-癸-3-烯类化合物的合成

Molecular diversity of tonghaosu analogs synthesis of 2-(Z)- benzylidene-1,6,9-trioxaspiro[4,5] dec-3-ene

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茼蒿素类似物的分子多样性2-(Z)-亚苄基-1,6,9-三氧杂螺环 [4,5-癸-3-烯类化 合物的合成

Molecular diversity of tonghaosu analogs synthesis of 2-(Z)- benzylidene-1,6,9-trioxaspiro[4,5] dec-3-ene

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Abstract

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Related Articles 15

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茼蒿素类似物的分子多样性2-(Z)-亚苄基-1,6,9-三氧杂螺环 [4,5-癸-3-烯类化合物的合成