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Acta Chimica Sinica ›› 2011, Vol. 69 ›› Issue (02): 204-208. Previous Articles     Next Articles

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复方板蓝根颗粒抗病毒成分HPLC-UV指纹图谱及LC-ESI-MSn研究

闫峻1，刘舒2，皮子凤2，宋凤瑞2，刘忠英*,1，刘志强2   

  1. (1吉林大学药学院 长春 130021)
    (2中国科学院长春应用化学研究所 长春 130022)
  • 投稿日期:2010-05-31 修回日期:2010-08-28 发布日期:2010-09-26
  • 通讯作者: 刘舒 E-mail:mslab20@ciac.jl.cn
  • 基金资助:

    国家“十一五”科技支撑计划

Studies on Fingerprint Chromatograms of Anti-virus Component of Compound Indigowoad Root Granule by HPLC-UV and LC-ESI-MSn

Yan Jun1 Liu Shu2 Pi Zifeng2 Song Fengrui2 Liu Zhongying*,1 Liu Zhiqiang2   

  1. (1 College of Pharmacy, Jilin University, Changchun 130021)
    (2 Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022)
  • Received:2010-05-31 Revised:2010-08-28 Published:2010-09-26
  • Contact: shu liu E-mail:mslab20@ciac.jl.cn

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The fingerprint chromatograms of the extracts from Compound Indigowoad Root Granule was established by HPLC-UV. Nineteen common peaks were found in fingerprint chromatograms of the extracts from Compound Indigowoad Root Granule and good similarities with correlation coefficients over 93% were found between the fingerprint chromatograms of the extracts from different sources. The main common peaks were identificated by HPLC-MSn. Pharmacodynamic studies have shown that the extract from Compound Indigowoad Root Granule had anti-viral activity. This method with desirable accuracy, stability and repeatability can be used for the quality evaluation of Compound Indigowoad Root Granule.

Key words: Compound Indigowoad Root Granule, fingerprint chromatograms, HPLC-MSn, anti-viral activity