Acta Chimica Sinica ›› 2011, Vol. 69 ›› Issue (08): 973-980. Previous Articles     Next Articles

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  1. (1河南师范大学化学与环境科学学院 黄淮水环境与污染防治省部共建教育部重点实验室 河南省环境污染控制重点实验室 新乡 453007)
    (2新乡医学院公共卫生学系 新乡 453003)
  • 收稿日期:2010-08-01 修回日期:2010-11-03 出版日期:2011-04-28 发布日期:2010-12-31
  • 通讯作者: 樊静
  • 基金资助:


Preparation and Separation Properties of Gatifloxacin Molecularly Imprinted Polymer Microsphere

Zhu Guifen1 Gao Yanbu1 Gao Xia1,2 Fan Jing*,1   

  1. (1 School of Chemistry and Environmental Science, Key Laboratory for Yellow River and Huai River Water Environment and Pollution Control of Ministry of Education, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang 453007)
    (2 School of Public Health, Xinxiang Medical University, Xinxiang 453003)
  • Received:2010-08-01 Revised:2010-11-03 Online:2011-04-28 Published:2010-12-31
  • Contact: jing fan

The gatifloxacin molecularly imprinted polymer (MIP) microsphere was prepared via precipitation polymerization. The morphologies and structures of the microsphere were characterized, and the polymerization reaction conditions were optimized. The static adsorption experiments were performed to investigate the adsorption properties and selective recognition characteristics of the polymer for the template molecule and its structural analogues. The results showed that the adsorption equilibrium of MIP for the substrates was achieved in 40 min under the optimized conditions. There existed two types of binding sites in the MIP, and the maximum adsorption capacities of specific and non-specific sites were 363 and 458 µmol/g, respectively. Compared with the corresponding non-imprinted polymer, the MIP exhibited better selective adsorption performance for quinolone antibiotics. The MIP prepared by precipitation polymerization was easy to regeneration, and it still could recognize effectively quinolone antibiotics 3 months later.

Key words: gatifloxacin, molecularly imprinted polymer, specific adsorption