Acta Chimica Sinica ›› 2004, Vol. 62 ›› Issue (17): 1621-1625. Previous Articles     Next Articles


唐课文, 陈国斌, 易健民, 张伟珍   

  1. 湖南理工学院化学化工系, 岳阳, 414000
  • 投稿日期:2004-01-13 修回日期:2004-04-12 发布日期:2014-02-17
  • 通讯作者:
  • 作者简介:唐课文
  • 基金资助:

Enantioselective Separation of Ofloxacin Enantiomers by Chiral Ligand Exchange

TANG Ke-Wen, CHEN Guo-Bin, YI Jian-Min, ZHANG Wei-Zhen   

  1. Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414000
  • Received:2004-01-13 Revised:2004-04-12 Published:2014-02-17

Based on chiral ligand exchange, the distribution behavior of ofloxacin enantiomers in the two-phase system containing copper(Ⅱ) ion (Cu2+) and N-n-dodecyl-L-proline (L) was studied.At different pH, the partition of Cu2+ in the two-phase system containing N-n-dodecyl-L-proline, was investigated.The influence of pH, concentrations of Cu2+ and chiral ligand on partition coefficients (K) and separation factors (α) was discussed.The experimental results show that L forms more stable ternary complex with R-ofloxacin enantiomer than with S-enantiomer.There is a large influence of pH on K and α.At low pH values (3.5), formation of binary complexes is thermodynamically unfavourable.K and α are the best when pH values are above 3.5 and the molar ratio of chiral ligand to Cu2+ is 2:1.The concentration ratio of S to R (1.72) was obtained in the aqueous phase by 2×1 hollow fiber membrane extraction.

Key words: ligand exchange, extraction, chiral separation, ofloxacin enantiomer