Synthesis and anti-PRV virus activity of novel N-pyridinium bipyrazole dimer derivatives

doi:10.23/cjoc202309017

Chinese Journal of Organic Chemistry

新型含N-吡啶联吡唑类二聚体衍生物的合成及抗PRV病毒活性评价

侯学会^a, 姚晨^c, 宋锦清^b, 杨菲菲^b, 何张旭^b, 陈晓培^a, 张京玉^b,*

^a河南牧业经济学院理学部郑州 450046;
^b河南中医药大学药学院郑州 450046;
^c河南农业大学动物医学院郑州 450046

收稿日期:2023-09-18 修回日期:2023-12-15
基金资助:
河南省自然科学基金项目(No. 202300410264)、河南省科技攻关项目(No. 232102111051)和中国博士后科学基金(2022M721060)资助项目

Synthesis and anti-PRV virus activity of novel N-pyridinium bipyrazole dimer derivatives

Hou Xuehui^a, Yao Chen^c, Song Jinqing^b, Yang Feifei^b, He Zhangxu^b, Chen Xiaopei^a, Zhang Jingyu^b,*

^aFaculty of Science, Henan University of Animal Husbandry and Economy, Zhengzhou 450046;
^bHenan University of Traditional Chinese Medicine, School of Pharmacy, Zhengzhou, 450046;
^cFaculty of Science, Henan University of Animal Husbandry and Economy, Zhengzhou 450046

Received:2023-09-18 Revised:2023-12-15
Contact: * E-mail: jyzhang2004@126.com
Supported by:
Natural Science Foundation of Henan Province (No. 202300410264) and the Key Scientific,Technological Project of He-nan Province (No. 232102111051) and China Postdoctoral Science Foundation (2022M721060).

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Abstract

The porcine pseudorabies virus (PRV) leading to severe neurological and respiratory damage can infects a wide range of vertebrates and humans, which raises concerns regarding the potential cross-species transmission of PRV. However, there is currently a lack of specific antiviral treatments available for PRV. In this study, we designed and synthesized 25 dimer derivatives containing N-pyridine bipyrazole moiety based on the principles of molecular splicing and electron isoarrangement. The structures of these compounds were characterized using ¹H NMR and ¹³C NMR analysis. Preliminary bioassay revealed that most of the compounds exhibited potent anti-PRV activity at a concentration of 10 μM while demonstrating no or minimal toxicity towards PK-15 cells. These novel N-pyridinium bipyrazole dimer derivatives could be regarded as anti-PRV agents for further optimization and development.

Key words: N-pyridinium bipyrazole, dimer derivatives, anti-PRV virus activity

Cite this article

Hou Xuehui, Yao Chen, Song Jinqing, Yang Feifei, He Zhangxu, Chen Xiaopei, Zhang Jingyu. Synthesis and anti-PRV virus activity of novel N-pyridinium bipyrazole dimer derivatives[J]. Chinese Journal of Organic Chemistry, doi: 10.23/cjoc202309017.

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新型含N-吡啶联吡唑类二聚体衍生物的合成及抗PRV病毒活性评价

Synthesis and anti-PRV virus activity of novel N-pyridinium bipyrazole dimer derivatives

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