Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (02): 389-405.DOI: 10.6023/cjoc201208002 Previous Articles     Next Articles




  1. 拜耳技术工程(上海)有限公司 上海201507
  • 收稿日期:2012-08-03 修回日期:2012-09-26 发布日期:2012-10-08
  • 通讯作者: 赵东波

Updated Applications of Flow Chemistry in Pharmaceutical Synthesis

Zhao Dongbo   

  1. Bayer Technology and Engineering (Shanghai) Co. Ltd., Shanghai 201507
  • Received:2012-08-03 Revised:2012-09-26 Published:2012-10-08

As a further-developing process intensification technology, flow chemistry has achieved a striking development either in academic or industrial area in the past decade. Updated applications of flow chemistry in pharmaceutical synthesis are overviewed. Compared with its early research and development (R&D), current flow chemistry has already shown a lot of breakthroughs. For instance, no more limitations to the proof of feasibility concept for some certain reaction, public development of this technology by more and more distinguished international pharmaceutical companies and quite a few corresponding reports of successful examples about multistep total synthesis of active pharmaceutical ingredients (APIs). Different process categorizations are emphasized with many API syntheses to demonstrate the up-to-date progress of this topic, after a brief introduction of the advantages, existing challenges and the corresponding solutions for flow chemistry.

Key words: flow chemistry, microreactor, microreaction technology, API synthesis, multistep flow synthesis, process categorization