Synthesis of Pyrano[2,3-c]pyrazoles Catalyzed by Poly(ethylene glycol) Bridged Triethylamine Functionalized Dication Ionic Liquid

doi:10.6023/cjoc201301034

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (9): 2016-2021.DOI: 10.6023/cjoc201301034 Previous Articles Next Articles

Notes

三乙胺功能化聚乙二醇双子离子液体催化合成吡喃并[2,3-c]吡唑

王英磊, 罗军, 邢昙昙, 刘祖亮

南京理工大学化工学院南京 210094

收稿日期:2013-01-15 修回日期:2013-03-21 发布日期:2013-05-06
通讯作者: 罗军 E-mail:luojun@njust.edu.cn
基金资助:
国家自然科学基金(No. 21002050)资助项目

Synthesis of Pyrano[2,3-c]pyrazoles Catalyzed by Poly(ethylene glycol) Bridged Triethylamine Functionalized Dication Ionic Liquid

Wang Yinglei, Luo Jun, Xing Tantan, Liu Zuliang

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094

Received:2013-01-15 Revised:2013-03-21 Published:2013-05-06
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21002050)

1. Synthesis of Pyrano[2,3-c]pyrazoles Catalyzed by Poly(ethylene glycol) Bridged Triethylamine Functionalized Dication Ionic Liquid.PDF(386KB)

Abstract

A novel PEG-800 bridged triethylamine functionalized dicationic ionic liquid PEG₈₀₀-DEIL(Cl) was synthesized and characterized. It was used as an efficient and recyclable catalyst for the synthesis of substituted pyrano[2,3-c]pyrazoles with excellent yields through a one-pot four-component reaction of aromatic aldehydes, malononitrile, ethyl acetoacetate, hydrazine hydrate or phenylhydrazine in water. The environmentally benign protocol was found to be fairly efficient and wide substrate flexibility. The catalytic system could be reused for at least five times without obvious loss of catalytic activity.

Key words: basic ionic liquid, poly(ethylene glycol), pyrano[2,3-c]pyrazole, one-pot, aqueous reaction

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Wang Yinglei, Luo Jun, Xing Tantan, Liu Zuliang. Synthesis of Pyrano[2,3-c]pyrazoles Catalyzed by Poly(ethylene glycol) Bridged Triethylamine Functionalized Dication Ionic Liquid[J]. Chin. J. Org. Chem., 2013, 33(9): 2016-2021.

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三乙胺功能化聚乙二醇双子离子液体催化合成吡喃并[2,3-c]吡唑

Synthesis of Pyrano[2,3-c]pyrazoles Catalyzed by Poly(ethylene glycol) Bridged Triethylamine Functionalized Dication Ionic Liquid

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