Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (06): 1186-1194.DOI: 10.6023/cjoc201303056 Previous Articles     Next Articles

Reviews

斯替宁碱的合成方法研究进展

陈静波, 陈景超, 谢彦, 刘娜娜, 刘丹丹, 张洪彬   

  1. 云南大学自然资源药物化学教育部重点实验室 昆明 650091
  • 收稿日期:2013-03-31 修回日期:2013-05-21 发布日期:2013-05-24
  • 通讯作者: 张洪彬 E-mail:zhonghb@ynu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21062029, 20562013及20925205)资助项目.

Research Progress on the Synthesis of Stenine

Chen Jingbo, Chen Jingchao, Xie Yan, Liu Nana, Liu Dandan, Zhang Hongbin   

  1. Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan University, Kunming 650091
  • Received:2013-03-31 Revised:2013-05-21 Published:2013-05-24
  • Supported by:

    Project supported by the the National Natural Science Foudation of China (Nos.21062029, 20562013, 20925205).

The alkaloid stenine which has a representative pyrrolo[1,2-a]azepine nucleus and a highly substituted perhydroindole ring system is unique among Stemona alkaloids.The polycyclic system and the seven contiguous stereogenic centers in (-)-stenine present a challenge for asymmetric organic synthesis.Progresses toward the synthesis of stenine are reviewed in terms of the key strategies employed.

Key words: stenine, racemic synthesis, asymmitric synthesis