Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (3): 509-521.DOI: 10.6023/cjoc201412056 Previous Articles     Next Articles



朱辉, 严冰玉, 曹杨, 陈知远   

  1. 江西师范大学化学化工学院 功能有机小分子教育部重点实验室 南昌 330022
  • 收稿日期:2014-12-31 修回日期:2015-02-01 发布日期:2015-02-02
  • 通讯作者: 陈知远
  • 基金资助:

    国家自然科学基金(Nos. 21202065, 21462022)和江西省自然科学基金(No. 20142BAB213004)资助项目.

Transition-Metal-Catalyzed Highly Selective Electrophilic Cycloisomerization Reaction of Multi-alkynyl Compounds

Zhu Hui, Yan Bingyu, Cao Yang, Chen Zhiyuan   

  1. Key Laboratory of Functional Small Organic Molecules, Ministry of Education, College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang 330022
  • Received:2014-12-31 Revised:2015-02-01 Published:2015-02-02
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21202065, 21462022), and the Natural Science Foundation of Jiangxi Province (No. 20142BAB213004).

This article summarized our recent progress in transition-metal-catalyzed highly selective cycloisomerization reactions of 1,5- and/or 1,6-diylol compounds, which selectively provided useful access to polyfunctionalized benzo[a]fluorenol and densely trisubstituted naphthalene derivatives. Based on these results, we have also developed transition-metal-catalyzed tandem cycloisomerization reactions of 1,6-diynl esters or 1,5-diyls, affording a series of methelene benzofulvenes derivatives and trifluoromethanesulfanyl benzofulvenes in chemo- and regio-selective manner. In addition, the factors that may affect the reaction processes were studied, and the possible reaction mechanisms are proposed.

Key words: transition-metal-catalyzed, multi-alkynyl compounds, cycloisomerization, tandem reaction