Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (11): 2437-2440.DOI: 10.6023/cjoc201505029 Previous Articles     Next Articles



刘泺, 潘敏, 周静珊, 杨金纬   

  1. 浙江医药股份有限公司新昌制药厂 绍兴 312500
  • 收稿日期:2015-05-18 修回日期:2015-06-18 发布日期:2015-07-02
  • 通讯作者: 杨金纬

Process Improvement on the Synthesis of Telavancin-Derivative of Vancomycin

Liu Luo, Pan Min, Zhou Jinshan, Yang Jinwei   

  1. Zhejiang Medicine Co., Ltd. Xinchang Pharma, Shaoxing 312500
  • Received:2015-05-18 Revised:2015-06-18 Published:2015-07-02

This article was the process improvement of telavancin synthesis. The key intermediate N-Fmoc-decyl-amino- acetaldehyde was obtained through continuous reaction method, followed by one-pot condensation and Mannich reaction. Telavancin hydrochloride was finnally obtained via reversed phase silica gel. The HPLC purity and total yield of this route were higher than the existing literatures. It was easy to operate, environmentally friendly, lower costs, and suitable for industrialized production.

Key words: telavancin, vancomycin, process improvement