Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (8): 1805-1813.DOI: 10.6023/cjoc201602018 Previous Articles     Next Articles



李振a, 段伟良b   

  1. a 上海应用技术学院 化学与环境工程学院 上海 201418;
    b 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032
  • 收稿日期:2016-02-19 修回日期:2016-04-20 发布日期:2016-04-29
  • 通讯作者: 段伟良
  • 基金资助:

    国家自然科学基金(Nos. 20902099,21172238,21472218)资助项目.

Recent Advances in the Asymmetric Conjugate Addition Reactions of Phosphorus Nucleophiles to Electron-Deficient Alkenes

Li Zhena, Duan Weiliangb   

  1. a School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418;
    b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2016-02-19 Revised:2016-04-20 Published:2016-04-29
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 20902099, 21172238, 21472218).

Chiral phosphines are very useful in the fields of asymmetric catalysis, pharmaceutical chemistry, and materials. These compounds have been used as ligands coordinated to transition metals or organocatalysts in various reactions to furnish optically active products with high efficiency. Asymmetric phosphorus-addition reaction can be utilized for the direct preparation of chiral phosphorus compounds. This review summarizes the recent progress in the field of enantioselective phosphorus-addition reactions. Several examples of transition metal- and organocatalyst-promoted asymmetric hydrophosphination reactions of electron-deficient alkenes have been introduced.

Key words: asymmetric addition, phosphorus nucleophiles, chiral phosphorus compounds, electron-deficient alkenes