Simple Synthesis of Bicyclic Pyrrole Ketone Compounds

doi:10.6023/cjoc201604004

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (10): 2437-2441.DOI: 10.6023/cjoc201604004 Previous Articles Next Articles

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双环吡咯酮类化合物的简便合成

孔令斌, 杨瑞霞, 杜璇璇, 严胜骄, 林军

云南大学化学科学与工程学院教育部自然资源药物化学重点实验室昆明 650091

收稿日期:2016-04-03 修回日期:2016-05-13 发布日期:2016-06-02
通讯作者: 严胜骄,E-mail:yansj@ynu.edu.cn;林军,E-mail:linjun@ynu.edu.cn E-mail:yansj@ynu.edu.cn;linjun@ynu.edu.cn
基金资助:
国家自然科学基金（Nos.U1202221，21362042，21662042）、云南省后备人才（No.2012HB001）和云南大学青年英才计划（No.XT412003）资助项目.

Simple Synthesis of Bicyclic Pyrrole Ketone Compounds

Kong Lingbin, Yang Ruixia, Du Xuanxuan, Yan Shengjiao, Lin Jun

School of Chemical Science And Technology, Yunnan University, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Kunming 650091

Received:2016-04-03 Revised:2016-05-13 Published:2016-06-02
Supported by:
Project supported by the National Natural Science Foundation of China (Nos.U1202221, 21362042, 21662042), the Talent Found in Yunnan Province (No.2012HB001), and the Excellent Young Talents in Yunnan University (No.XT412003).

1. Simple Synthesis of Bicyclic Pyrrole Ketone Compounds.PDF(868KB)

Abstract

In this article, a one-pot protocol was established for the synthesis of bicyclic pyrrole ketone compounds. This method based on the building blocks of heterocyclic ketene aminals 1, which reacted with oxalaldehyde 2 in 1,4-dioxane at 50℃ and triethylamine as base. As a result, a series of bicyclic pyrrole ketone compounds 3a~3i have been synthesized. This reaction has some advantages such as simple synthetic route, readily available starting materials, high yields and simple work-up procedures.

Key words: bicyclic pyrrole ketone, heterocyclic ketene aminals, oxalaldehyde

Cite this article

Kong Lingbin, Yang Ruixia, Du Xuanxuan, Yan Shengjiao, Lin Jun. Simple Synthesis of Bicyclic Pyrrole Ketone Compounds[J]. Chin. J. Org. Chem., 2016, 36(10): 2437-2441.

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双环吡咯酮类化合物的简便合成

Simple Synthesis of Bicyclic Pyrrole Ketone Compounds

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