Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (11): 2752-2756.DOI: 10.6023/cjoc201605044 Previous Articles     Next Articles



周宗宝, 王红, 陶凯奇, 叶晓川, 胡春玲   

  1. 湖北中医药大学药学院 中药化学与中药资源省级重点实验室 武汉 430065
  • 收稿日期:2016-05-30 修回日期:2016-06-25 发布日期:2016-07-15
  • 通讯作者: 胡春玲
  • 基金资助:


A Facile Method to Prepare Dihydroflavonol Derivatives

Zhou Zongbao, Wang Hong, Tao Kaiqi, Ye Xiaochuan, Hu Chunling   

  1. Key Laboratory of Chinese Medicine Chemistry and Chinese Herbal Compound of Hubei Province, College of Pharmacy, Hubei University of Traditional Chinese Medicine, Wuhan 430065
  • Received:2016-05-30 Revised:2016-06-25 Published:2016-07-15
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.31370378).

A series of dihydroflavonol derivatives were synthesized by the reaction of 2'-hydroxyl chalcone derivatives with H2O2/(CH3CH2)2NH system in anhydrous tetrahydrofuran under low temperature. The influences of reaction temperature, re-action solvents, the kinds and proportion of alkaline additive and oxidants on this reaction were investigated, and the optimal reaction conditions were determined. This method has the advantages of simple operation, mild conditions and convenient post-treatment. Besides, all synthetic products were fully characterized by NMR spectra.

Key words: 2'-hydroxyl chalcone derivatives, dihydroflavonol derivatives, facile method