Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (7): 1850-1854.DOI: 10.6023/cjoc201612057 Previous Articles     Next Articles



陈锦杨a, 吴小波b, 易荣楠a, 许新华a   

  1. a. 湖南大学化学化工学院 长沙 410082;
    b. 湖北省纤维检验局 武汉 420100
  • 收稿日期:2016-12-24 修回日期:2017-02-21 发布日期:2017-03-14
  • 通讯作者: 许新华
  • 基金资助:


Nickel-Catalyzed Coupling of Grignard Reagents and Diaryl Acetylenes for Synthesis of Tetra-substituted Naphthalenes

Chen Jinyanga, Wu Xiaobob, Yi Rongnana, Xu Xinxuaa   

  1. a. College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082;
    b. Fiber Inspection Bureau of Hubei Province, Wuhan 420100
  • Received:2016-12-24 Revised:2017-02-21 Published:2017-03-14
  • Contact: 10.6023/cjoc201612057
  • Supported by:

    Project supported by the Hunan Provincal Science and Technology Major Projects (No.2014FJ1010).

A novel approach for the synthesis of tetra-substituted naphthalenes is demonstrated through the ligand-free coupling of a wide range of alkynes with Grignard reagents catalyzed by NiCl2, avoiding the use of special ligands and expensive catalysts used in previous methods. Other outstanding features include mild reaction conditions, good yields and wide functional group tolerance. The protocol provides an efficient method for the synthesis of highly substituted naphthalenes.

Key words: nickel-catalyzed coupling, tetra-substituted naphthalenes, Grignard reagents, diaryl acetylene