Diterpenoid Alkaloids from Aconitum leucostomum and Their Antifeedant Activity

doi:10.6023/cjoc201702021

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (7): 1839-1843.DOI: 10.6023/cjoc201702021 Previous Articles Next Articles

Notes

白喉乌头中二萜生物碱及其拒食活性研究

陈琳^a,b,c, 王倩^a, 黄帅^a, 单连海^a, 高峰^a, 周先礼^a,b

a. 西南交通大学生命科学与工程学院成都 610031;
b. 西南交通大学材料科学与工程学院成都 610031;
c. 西华师范大学化学化工学院南充 637002

收稿日期:2017-02-16 修回日期:2017-03-09 发布日期:2017-04-01
通讯作者: 周先礼 E-mail:zhouxl@swjtu.edu.cn
基金资助:
国家自然科学基金（No.81402803）、四川省小分子天然药物创新团队（No.15TD0048）、四川省教育厅项目（No.15ZB0140）、中央高校基本科研业务费专项（No.2682017QY04）资助项目.

Diterpenoid Alkaloids from Aconitum leucostomum and Their Antifeedant Activity

Chen Lin^a,b,c, Wang Qian^a, Huang Shuai^a, Shan Lianhai^a, Gao Feng^a, Zhou Xianli^a,b

a. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031;
b. School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031;
c. School of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002

Received:2017-02-16 Revised:2017-03-09 Published:2017-04-01
Contact: 10.6023/cjoc201702021 E-mail:zhouxl@swjtu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No.81402803),the Small Molecule Natural Medicine Innovation Team (No.15TD0048),the Research Foundation for Educational Commission of Sichuan Province (No.15ZB0140) and the Fundamental Research Funds for Central Universities (No.2682017QY04).

1. Diterpenoid Alkaloids from Aconitum leucostomum and Their Antifeedant Activity.PDF(838KB)

Abstract

A new C₁₈ diterpenoid alkaloid,leucostonine(1),was isolated from the whole plant of Aconitum leucostomum Vorosch.,together with twelve known diterpenoid alkaloids.Their structures were elucidated on the basis of extensive spectroscopic analysis,including HR-ESI-MS,1D NMR and 2D NMR spectra.12 compounds were tested for their antifeedant activity against larvae of Spodoptera exigua Hiibner.Anthranoyllycoctonine and avadharidine showed considerable potent antifeedant activity(EC₅₀<1 mg/cm²),followed by N-acetylsepaconitine,finaconitine and N-deacetylappaconitine(EC₅₀<2 mg/cm²).

Key words: aconitum, Aconitum leucostomum, diterpenoid alkaloid, leucostonine, antifeedant activity

Cite this article

Chen Lin, Wang Qian, Huang Shuai, Shan Lianhai, Gao Feng, Zhou Xianli. Diterpenoid Alkaloids from Aconitum leucostomum and Their Antifeedant Activity[J]. Chin. J. Org. Chem., 2017, 37(7): 1839-1843.

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白喉乌头中二萜生物碱及其拒食活性研究

Diterpenoid Alkaloids from Aconitum leucostomum and Their Antifeedant Activity

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