Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (7): 1839-1843.DOI: 10.6023/cjoc201702021 Previous Articles     Next Articles



陈琳a,b,c, 王倩a, 黄帅a, 单连海a, 高峰a, 周先礼a,b   

  1. a. 西南交通大学生命科学与工程学院 成都 610031;
    b. 西南交通大学材料科学与工程学院 成都 610031;
    c. 西华师范大学化学化工学院 南充 637002
  • 收稿日期:2017-02-16 修回日期:2017-03-09 发布日期:2017-04-01
  • 通讯作者: 周先礼
  • 基金资助:


Diterpenoid Alkaloids from Aconitum leucostomum and Their Antifeedant Activity

Chen Lina,b,c, Wang Qiana, Huang Shuaia, Shan Lianhaia, Gao Fenga, Zhou Xianlia,b   

  1. a. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031;
    b. School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031;
    c. School of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002
  • Received:2017-02-16 Revised:2017-03-09 Published:2017-04-01
  • Contact: 10.6023/cjoc201702021
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.81402803),the Small Molecule Natural Medicine Innovation Team (No.15TD0048),the Research Foundation for Educational Commission of Sichuan Province (No.15ZB0140) and the Fundamental Research Funds for Central Universities (No.2682017QY04).

A new C18 diterpenoid alkaloid,leucostonine(1),was isolated from the whole plant of Aconitum leucostomum Vorosch.,together with twelve known diterpenoid alkaloids.Their structures were elucidated on the basis of extensive spectroscopic analysis,including HR-ESI-MS,1D NMR and 2D NMR spectra.12 compounds were tested for their antifeedant activity against larvae of Spodoptera exigua Hiibner.Anthranoyllycoctonine and avadharidine showed considerable potent antifeedant activity(EC50<1 mg/cm2),followed by N-acetylsepaconitine,finaconitine and N-deacetylappaconitine(EC50<2 mg/cm2).

Key words: aconitum, Aconitum leucostomum, diterpenoid alkaloid, leucostonine, antifeedant activity