Triterpenoid Glycosides from the Leaves of Lyonia ovalifolia var. hebecarpa and Their Antitumor Activities

doi:10.6023/cjoc201705007

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (9): 2416-2422.DOI: 10.6023/cjoc201705007 Previous Articles Next Articles

Notes

毛果南烛叶中的三萜皂苷化合物及其抗肿瘤活性

滕杨^a,b,c, 张涵淇^b, 周俊飞^b, 李永吉^a, 姚广民b^b

a 黑龙江中医药大学药学院哈尔滨 150040;
b 华中科技大学同济医学院药学院武汉 430030;
c 佳木斯大学药学院佳木斯 1504007

收稿日期:2017-05-03 修回日期:2017-05-19 发布日期:2017-05-25
通讯作者: 姚广民, 李永吉 E-mail:gyap@mail.hust.edu.cn;liyongji2009@163.com
基金资助:
中央高校基本科研业务费基金（No.2016YXMS148）资助项目.

Triterpenoid Glycosides from the Leaves of Lyonia ovalifolia var. hebecarpa and Their Antitumor Activities

Teng Yang^a,b,c, Zhang Hanqi^b, Zhou Junfei^b, Li Yongji^a, Yao Guangmin^b

a Scholl of Pharmacy, Heilongjiang University of Chinese Medicine, Haerbin 150040;
b School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030;
c College of Pharmacy, Jiamusi University, Jiamusi 154007

Received:2017-05-03 Revised:2017-05-19 Published:2017-05-25
Contact: 10.6023/cjoc201705007 E-mail:gyap@mail.hust.edu.cn;liyongji2009@163.com
Supported by:
Project supported by the Fundamental Research Funds for the Central Universities (No. 2016YXMS148).

1. Triterpenoid Glycosides from the Leaves of Lyonia ovalifolia var. hebecarpa and Their Antitumor Activities.PDF(3060KB)

Abstract

Three triterpenoid glycosides were isolated from the leaves of Lyonia ovalifolia var. hebecarpa by separation techniques such as column chromatograph and HPLC, and their structures were determined to be 3β-O-α-L-arabinopyranosyloxy-olean-12-ene-23,25-diol (1), 3β-O-α-L-arabinopyranosyloxy-olean-12-ene-1β,23-diol (2), and 3α-[(β-D-glucopyranosyl)-oxy]-24α-[(α-L-arabinopyranosyl)-oxy]-25-hydroxy-9,10-seco-cycloaran-1(10)-en-30-oic acid (3), respectively, by HRESIMS and NMR data analysis, as well as chemical methods. Compound 1 and its aglycone are new compounds, and compounds 2 and 3 were isolated from Lyonia ovalifolia var. hebecarpa for the first time. This is the first report of the NMR data assignment of compound 2 and its aglycone. The in vitro anti-tumor activities of compounds 1~3 were evaluated, and compound 2 showed anti-proliferation activities against five cancer cell lines HL-60, MCF-7, SMMC-7221, A-549 and SW480 with IC₅₀ values of (16.35±0.25), (17.05±0.52), (17.66±0.21), (15.87±0.26) and (12.30±0.36) μmol·L^-1, respectively, and showed more potent anti-proliferation than the positive control, cis-platin, against MCF-7, A-549, and SW480 cell lines.

Key words: Lyonia ovalifolia var. hebecarpa, ericaceae, Lyonia, triterpenoid glycosides, antitumor activities

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Teng Yang, Zhang Hanqi, Zhou Junfei, Li Yongji, Yao Guangmin. Triterpenoid Glycosides from the Leaves of Lyonia ovalifolia var. hebecarpa and Their Antitumor Activities[J]. Chin. J. Org. Chem., 2017, 37(9): 2416-2422.

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毛果南烛叶中的三萜皂苷化合物及其抗肿瘤活性

Triterpenoid Glycosides from the Leaves of Lyonia ovalifolia var. hebecarpa and Their Antitumor Activities

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