Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (9): 2416-2422.DOI: 10.6023/cjoc201705007 Previous Articles     Next Articles



滕杨a,b,c, 张涵淇b, 周俊飞b, 李永吉a, 姚广民bb   

  1. a 黑龙江中医药大学药学院 哈尔滨 150040;
    b 华中科技大学同济医学院药学院 武汉 430030;
    c 佳木斯大学药学院 佳木斯 1504007
  • 收稿日期:2017-05-03 修回日期:2017-05-19 发布日期:2017-05-25
  • 通讯作者: 姚广民, 李永吉;
  • 基金资助:


Triterpenoid Glycosides from the Leaves of Lyonia ovalifolia var. hebecarpa and Their Antitumor Activities

Teng Yanga,b,c, Zhang Hanqib, Zhou Junfeib, Li Yongjia, Yao Guangminb   

  1. a Scholl of Pharmacy, Heilongjiang University of Chinese Medicine, Haerbin 150040;
    b School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030;
    c College of Pharmacy, Jiamusi University, Jiamusi 154007
  • Received:2017-05-03 Revised:2017-05-19 Published:2017-05-25
  • Contact: 10.6023/cjoc201705007;
  • Supported by:

    Project supported by the Fundamental Research Funds for the Central Universities (No. 2016YXMS148).

Three triterpenoid glycosides were isolated from the leaves of Lyonia ovalifolia var. hebecarpa by separation techniques such as column chromatograph and HPLC, and their structures were determined to be 3β-O-α-L-arabinopyranosyloxy-olean-12-ene-23,25-diol (1), 3β-O-α-L-arabinopyranosyloxy-olean-12-ene-1β,23-diol (2), and 3α-[(β-D-glucopyranosyl)-oxy]-24α-[(α-L-arabinopyranosyl)-oxy]-25-hydroxy-9,10-seco-cycloaran-1(10)-en-30-oic acid (3), respectively, by HRESIMS and NMR data analysis, as well as chemical methods. Compound 1 and its aglycone are new compounds, and compounds 2 and 3 were isolated from Lyonia ovalifolia var. hebecarpa for the first time. This is the first report of the NMR data assignment of compound 2 and its aglycone. The in vitro anti-tumor activities of compounds 1~3 were evaluated, and compound 2 showed anti-proliferation activities against five cancer cell lines HL-60, MCF-7, SMMC-7221, A-549 and SW480 with IC50 values of (16.35±0.25), (17.05±0.52), (17.66±0.21), (15.87±0.26) and (12.30±0.36) μmol·L-1, respectively, and showed more potent anti-proliferation than the positive control, cis-platin, against MCF-7, A-549, and SW480 cell lines.

Key words: Lyonia ovalifolia var. hebecarpa, ericaceae, Lyonia, triterpenoid glycosides, antitumor activities