N-Heterocycle Synthesis via Gold-Catalyzed Intermolecular Nitrene Transfer Reactions of Alkynes

doi:10.6023/cjoc201708021

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (11): 2785-2799.DOI: 10.6023/cjoc201708021 Previous Articles Next Articles

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金催化分子间炔烃的氮烯转移反应合成含氮杂环化合物

廖云^a,b, 朱磊^b, 俞颖华^b, 陈贵^b, 黄学良^b

a 福州大学化学学院福州 350116;
b 中国科学院煤制乙二醇及相关技术重点实验室中国科学院福建物质结构研究所福州350002

收稿日期:2017-08-11 修回日期:2017-09-08 发布日期:2017-09-19
通讯作者: 陈贵, 黄学良 E-mail:chengui@fjirsm.ac.cn;huangxl@fjirsm.ac.cn
基金资助:
国家自然科学基金（Nos.2142197，21502190）、福建省自然科学基金（No.2017J0131）资助项目.

N-Heterocycle Synthesis via Gold-Catalyzed Intermolecular Nitrene Transfer Reactions of Alkynes

Liao Yun^a,b, Zhu Lei^b, Yu Yinghua^b, Chen Gui^b, Huang Xueliang^b

a College of Chemistry, Fuzhou University, Fuzhou 350116;
b Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002

Received:2017-08-11 Revised:2017-09-08 Published:2017-09-19
Contact: 10.6023/cjoc201708021 E-mail:chengui@fjirsm.ac.cn;huangxl@fjirsm.ac.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21402197, 21502190), and the Natural Science Foundation of Fujian Province (No. 2017J01031).

N-Heterocyclic rings are versatile structural units that widely dispersed in a variety of natural products, biological active species, and photoelectric materials. They are also useful building blocks in synthetic community. This review mainly focused on recent progress on gold-catalyzed intermolecular nitrene transfer reactions with alkynes. This strategy complements the toolbox for the synthesis of multisubstituted N-heterocyclic compounds. Mechanistically, activated by a suitable gold catalyst, the specific alkyne could react with a nitrene precursor, providing the final N-heterocyclic compounds in highly efficient manner.

Key words: gold-catalysis, ynamide, nitrene precursor, N-heterocycle, α-imino-gold-carbene

Cite this article

Liao Yun, Zhu Lei, Yu Yinghua, Chen Gui, Huang Xueliang. N-Heterocycle Synthesis via Gold-Catalyzed Intermolecular Nitrene Transfer Reactions of Alkynes[J]. Chin. J. Org. Chem., 2017, 37(11): 2785-2799.

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金催化分子间炔烃的氮烯转移反应合成含氮杂环化合物

N-Heterocycle Synthesis via Gold-Catalyzed Intermolecular Nitrene Transfer Reactions of Alkynes

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