Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (11): 2785-2799.DOI: 10.6023/cjoc201708021 Previous Articles     Next Articles



廖云a,b, 朱磊b, 俞颖华b, 陈贵b, 黄学良b   

  1. a 福州大学化学学院 福州 350116;
    b 中国科学院煤制乙二醇及相关技术重点实验室 中国科学院福建物质结构研究所 福州350002
  • 收稿日期:2017-08-11 修回日期:2017-09-08 发布日期:2017-09-19
  • 通讯作者: 陈贵, 黄学良;
  • 基金资助:


N-Heterocycle Synthesis via Gold-Catalyzed Intermolecular Nitrene Transfer Reactions of Alkynes

Liao Yuna,b, Zhu Leib, Yu Yinghuab, Chen Guib, Huang Xueliangb   

  1. a College of Chemistry, Fuzhou University, Fuzhou 350116;
    b Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002
  • Received:2017-08-11 Revised:2017-09-08 Published:2017-09-19
  • Contact: 10.6023/cjoc201708021;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21402197, 21502190), and the Natural Science Foundation of Fujian Province (No. 2017J01031).

N-Heterocyclic rings are versatile structural units that widely dispersed in a variety of natural products, biological active species, and photoelectric materials. They are also useful building blocks in synthetic community. This review mainly focused on recent progress on gold-catalyzed intermolecular nitrene transfer reactions with alkynes. This strategy complements the toolbox for the synthesis of multisubstituted N-heterocyclic compounds. Mechanistically, activated by a suitable gold catalyst, the specific alkyne could react with a nitrene precursor, providing the final N-heterocyclic compounds in highly efficient manner.

Key words: gold-catalysis, ynamide, nitrene precursor, N-heterocycle, α-imino-gold-carbene