Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (1): 29-39.DOI: 10.6023/cjoc201708065 Previous Articles     Next Articles

Special Issue: 庆祝吴养洁院士九十华诞专辑 有机超分子化学合辑



李臻益a, 胡晓玉a, 强琚莉a, 张冬梅b, 肖守军a, 林晨a, 王乐勇a   

  1. a 南京大学化学化工学院 南京 210023;
    b 南京大学生命科学学院 医药生物技术国家重点实验室 南京 210023
  • 收稿日期:2017-08-31 修回日期:2017-09-19 发布日期:2017-09-26
  • 通讯作者: 林晨
  • 基金资助:


Recent Advances in Closed-Loop and Smart Insulin Delivery Systems

Li Zhenyia, Hu Xiaoyua, Jiang Julia, Zhang Dongmeib, Xiao Shoujuna, Lin Chena, Wang Leyonga   

  1. a School of Chemistry and Chmeical Engineering, Nanjing University, Nanjing 210023;
    b State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023
  • Received:2017-08-31 Revised:2017-09-19 Published:2017-09-26
  • Contact: 10.6023/cjoc201708065
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21672102, 21572101).

Insulin is a commonly prescribed drug for the treatment of type I and type Ⅱ diabetes. As for the efficiency in controlling blood glucose level, insulin therapy is one of the most effective treatments for diabetes. The current administration route of insulin is mainly through subcutaneous injection, which leads to many undesirable side effects such as pain, local tissue necrosis or infection, and nerve damage. Recently, various closed-loop and smart insulin delivery systems have been developed based on the emerging nanotechnologies. Recent progress in the construction of closed-loop and smart insulin delivery system, which mainly focuses on the response mechanism, different strategies for fabricating the carrier matrix, and the regulation principle of the smart insulin release is described. Advantages and drawbacks of the current insulin delivery systems are also discussed, along with the opportunities and challenges in future.

Key words: diabetes, insulin, glucose-response, closed-loop delivery system, smart drug release