Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (3): 629-635.DOI: 10.6023/cjoc201709040 Previous Articles     Next Articles

Special Issue: 荧光探针-生物传感合辑 有机超分子化学合辑



黄青a,b, 曲文娟a, 陈洁c, 林奇a, 姚虹a, 张有明a, 魏太保a   

  1. a 西北师范大学化学化工学院 教育部生态环境相关材料重点实验室 甘肃省高分子材料重点实验室 兰州 730070;
    b 宁夏医科大学药学院 银川 750006;
    c 兰州城市学院 兰州 750070
  • 收稿日期:2017-09-25 修回日期:2017-10-31 发布日期:2017-11-17
  • 通讯作者: 魏太保,
  • 基金资助:


A Reaction Type Colorimetric and Fluorescence Chemosensor Based on Coumarin Derivatives Design for Detecting Cyanide Ion and Its Application

Huang Qinga,b, Qu Wenjuana, Chen Jiec, Lin Qia, Yao Honga, Zhang Youminga, Wei Taibaoa   

  1. a Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education;Key Laboratory of Polymer Materials of Gansu Province;College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070;
    b School of Pharmacy, Ningxia Medical University, Yinchuan 750006;
    c Lanzhou City University, Lanzhou 730070
  • Received:2017-09-25 Revised:2017-10-31 Published:2017-11-17
  • Contact: 10.6023/cjoc201709040
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21662031, 21661028, 21574104, 21262032).

A novel CN- chemosensor based N-4-pyridylcoumarin-3-carboxamide derivative Q1 was designed and synthesized. The recognition performance of sensor Q1 for ten different anions was studied by UV and fluorescence spectroscopy. When anions such as CN-, F-, Cl-, Br-, I-, AcO-, H2PO4-,HSO4-,ClO4- and SCN- were added to the mixed solution (DMSO/H2O, V:V=9:1), addition of CN- could increase the absorption peak of Q1 at 304 nm, and the corresponding fluorescence produced a strong emission peak at 431 nm. Q1 solution with CN- emitted strong blue fluorescent that can be easily observed by naked eyes. The color changed (from colorless to faint yellow) and the "Turn-On" fluorescence behavior suggested that Q1 could detect CN- by dual-channel. Happily, the fluorescent limit of detection (LOD) is 1.44×10-8 mol/L, was lower than the specified content by World Health Organization (WHO) in drinking water. Based on all the experimental facts, we speculated that the possible identification mechanism was that the addition reaction took place between Q1 and CN-, and it can also be confirmed by density functional theory (DFT). This result can be applied to the detection of CN- in cherry kernel.

Key words: coumarin derivatives, dual-channel, cyanide ions, food sample application