Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (1): 124-130.DOI: 10.6023/cjoc201709054 Previous Articles     Next Articles

Special Issue: 庆祝吴养洁院士九十华诞专辑



余海洋, 皮超, 王勇, 崔秀灵, 吴养洁   

  1. 郑州大学化学与分子工程学院 河南省化学生物与有机化学重点实验室 河南省高等学校应用化学重点开放实验室 郑州 450052
  • 收稿日期:2017-09-30 修回日期:2017-11-14 发布日期:2017-11-15
  • 通讯作者: 崔秀灵
  • 基金资助:


Iodine-Catalyzed Regioselective Sulfonylation of Quinoline N-Oxides with Sulfonyl Hydrazides

Yu Haiyang, Pi Chao, Wang Yong, Cui Xiuling, Wu Yangjie   

  1. Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052
  • Received:2017-09-30 Revised:2017-11-14 Published:2017-11-15
  • Contact: 10.6023/cjoc201709054
  • Supported by:

    Project supported by the Ministry of Science and Technology of China (No. 2016YFE0132600) and the Science and Technology Innovation Program of Universities in Henan Province (No. 16HASTIT007).

A novel and simple protocol has been developed for the regioselective sulfonylation of quinolone N-oxides at their C-2 postition. This method features with a simple system, high efficiency, environmental friendliness, and metal-free conditions. Aliphatic and aryl sulfonyl hydrazides smoothly undergo sulfonylation with quinoline N-oxides in good yields.

Key words: iodine-catalyzed, quinoline N-oxides, sulfonyl hydrazides